CAJ | 학술논문

目的研究我国南方社区健康人群椎-基底动脉颅内段狭窄的患病情况和危险因素.方法以居委会为单位随机整群抽取社区成年居民.测量身高、体重、腰围、臀围和血压,记录病史资料.空腹静脉采血检测血糖、甘油三酯、总胆固醇等.经颅多普勒超声(TCD)检测双侧椎动脉颅内段(VA)和基底动脉(BA)狭窄情况.用SPSS 11.0软件包进行数据统计分析.结果 1035名有效研究对象中,58例(5.6%)存在椎-基底动脉颅内段狭窄.其中左、右侧VA狭窄分别为17例和23例,BA狭窄30例.单因素分析提示,糖尿病患者中椎-基底动脉颅内段狭窄的患病率(10.3%)显著高于非糖尿病患者(3.2%,χ2=6.221,P=0.013);狭窄组人群平均收缩压水平[(131.1±25.5)mm Hg,1 mm Hg=0.133 kPa]显著高于非狭窄组[(124.1±21.6)mm Hg,t=2.228,P=0.026].Logistic回归分析证实糖尿病史和收缩压是椎-基底动脉颅内段狭窄的独立危险因素(糖尿病史:OR=3.305,P=0.023;收缩压升高1 mm Hg,OR=1.012,P=0.047).结论椎-基底动脉颅内段狭窄在我国成年人群中均有较高的发生率.收缩压的升高和糖尿病是椎-基底动脉颅内段狭窄的重要危险因素.
목적 연구아국남방사구건강인군추-기저동맥로내단협착적환병정황화위험인소.방법 이거위회위단위수궤정군추취사구성년거민.측량신고、체중、요위、둔위화혈압,기록병사자료.공복정맥채혈검측혈당、감유삼지、총담고순등.경로다보륵초성(TCD)검측쌍측추동맥로내단(VA)화기저동맥(BA)협착정황.용SPSS 11.0연건포진행수거통계분석.결과 1035명유효연구대상중,58례(5.6%)존재추-기저동맥로내단협착.기중좌、우측VA협착분별위17례화23례,BA협착30례.단인소분석제시,당뇨병환자중추-기저동맥로내단협착적환병솔(10.3%)현저고우비당뇨병환자(3.2%,χ2=6.221,P=0.013);협착조인군평균수축압수평[(131.1±25.5)mm Hg,1 mm Hg=0.133 kPa]현저고우비협착조[(124.1±21.6)mm Hg,t=2.228,P=0.026].Logistic회귀분석증실당뇨병사화수축압시추-기저동맥로내단협착적독립위험인소(당뇨병사:OR=3.305,P=0.023;수축압승고1 mm Hg,OR=1.012,P=0.047).결론 추-기저동맥로내단협착재아국성년인군중균유교고적발생솔.수축압적승고화당뇨병시추-기저동맥로내단협착적중요위험인소.
Objective To investigate the prevalence and risk factors of intracranial vertebrobasilar artery stenosis. Methods By cluster sampling, adult Han people were recruited from residential communities. Medical history was documented and body height, body weight, waist circumference, hip circumference and blood pressure were measured. Venous blood samples were collected to determine serum fasting glucose, total cholesterol and triglycerides concentrations. Intracranial vertebrobasilar artery stenosis was diagnosed with transcranial Doppler. The SPSS 11.0 software package was used for data analysis. Results Among 1035 people conforming to the inclusion criteria, intracranial vertebrobasilar artery stenosis was found in 58 (5.6%), 17 with left VA stenosis, 23 with right VA stenosis and 30 with BA stenosis.Univariate analysis showed that subjects with diabetes mellitus had a significantly higher prevalence ( 10. 3% ) of intracranial vertebrobasilar artery stenosis (χ2 = 6. 221, P = 0. 013 ) and the mean systolic blood pressure (( 131.1 ± 25.5) mm Hg, 1 mm Hg = 0. 133 kPa) in the subjects with stenosis was significantly higher than those without (3.2%, ( 124. 1 ± 21.6) mm Hg) (t = 2. 228, P = 0. 026). Logistic regression indicated that diabetes mellitus and systolic blood pressure were independent risk factors for intracranial vertebrobasilar artery stenosis ( diabetes mellitus: OR = 3. 305, P = 0. 023; elevated systolic blood pressure 1 mm Hg: OR = 1. 012, P =0. 047). Conclusions This study demonstrated a considerably high prevalence of intracranial vertebrobasilar artery stenosis in a southern Chinese population. Diabetes mellitus and systolic blood pressure play potent roles in intracranial vertebrobasilar artery stenosis.