CAJ | 학술논문

收集2008年7月至2010年6月的45例急性脑梗死患者,随机分为亚低温治疗组21例和对照组24例,对照组给予常规抗血小板等治疗,亚低温组在常规治疗基础上给予病灶侧局部亚低温治疗24 h.结果显示,与对照组相比,治疗组第14,30天美国国立卫生研究院卒中量表(NIHSS)评分明显降低(P＜0.05),第7,14天血中神经元特异性烯醇化酶、一氧化氮(NO)、白细胞介素-6和细胞问黏附分子-1含量明显降低,超氧化物歧化酶活力明显升高(P＜0.05).局部亚低温治疗可减轻急性脑梗死的炎症反应,减少自由基产生.
수집2008년7월지2010년6월적45례급성뇌경사환자,수궤분위아저온치료조21례화대조조24례,대조조급여상규항혈소판등치료,아저온조재상규치료기출상급여병조측국부아저온치료24 h.결과현시,여대조조상비,치료조제14,30천미국국립위생연구원졸중량표(NIHSS)평분명현강저(P＜0.05),제7,14천혈중신경원특이성희순화매、일양화담(NO)、백세포개소-6화세포문점부분자-1함량명현강저,초양화물기화매활력명현승고(P＜0.05).국부아저온치료가감경급성뇌경사적염증반응,감소자유기산생.
Forty five patients with acute cerebral infarction were randomized to two groups: in treatment group patients received local subhypothermia and conventional therapy, in control group patients received conventional therapy only. Clinical outcome was assessed by the National Institutes of Health Stroke Scale (NIHSS) on admission and at 7, 14 and 30 d after treatment. Serum neuron specific enolase (NSE), nitrogen monoxide ( NO ) , superoxide dismutase (SOD), interleukin-6 (IL-6 ) and intercellular adhesion molecule-1 (ICAM-1) were detected on admission and at 7,14 d after treatment The study showed that NIHSS scores of treatment group on 14, 30 d were lower than those of control group ( P ＜ 0. 05 ). Serum NSE, NO, IL-6 and ICAM-1 levels significantly decrease; while serum SOD levels increased (P ＜ 0. 05). In conclusion, local subhypothermia therapy can inhibit inflammatory reaction, reduce oxygen free radical formation and improve neurological function in patients with acute cerebral infarction.