CAJ | 학술논문

目的小细胞肺癌(SCLC)患者手术联合化疗和单纯化疗的生存期比较.方法收集1999-2004年吉林大学第一医院胸外科37例SCLC患者,术后用依托泊甘+顺铂或卡铂方案化疗4～6个疗程.选取37例年龄、分期及肿瘤部位相仿的对照组患者,用依托泊甘+顺铂或卡铂方案化疗6个疗程.两组分别随访5年,进行生存率比较.结果手术联合化疗组的1、3、5年总的生存率分别为72.97%、35.13%、21.62%.对照组1、3、5年总的生存率分别为54.05%、13.51%、5.41%.两组Ⅰ期SCLC生存率差异有统计学意义(P=0.01),Ⅱ和Ⅲ期差异无统计学意义(P=0.06,P=0.836).结论手术后联合化疗对Ⅰ期的SCLC具有良好的治疗效果.
목적 소세포폐암(SCLC)환자수술연합화료화단순화료적생존기비교.방법 수집1999-2004년길림대학제일의원흉외과37례SCLC환자,술후용의탁박감+순박혹잡박방안화료4～6개료정.선취37례년령、분기급종류부위상방적대조조환자,용의탁박감+순박혹잡박방안화료6개료정.량조분별수방5년,진행생존솔비교.결과 수술연합화료조적1、3、5년총적생존솔분별위72.97%、35.13%、21.62%.대조조1、3、5년총적생존솔분별위54.05%、13.51%、5.41%.량조Ⅰ기SCLC생존솔차이유통계학의의(P=0.01),Ⅱ화Ⅲ기차이무통계학의의(P=0.06,P=0.836).결론 수술후연합화료대Ⅰ기적SCLC구유량호적치료효과.
Objective To compare the survival time of surgery combine with chemotherapy with non-surgery chemotherapy in SCLC.Methods 37 SCLC post operation patients were received 4-6 cycles of chemotherapy of "etoposide + cisplatin or carboplatin".37 SCLC patients were selected be control group,whose age 、stage and site of tumor were similar to surgery combine with chemotherapy group,and received 6 cycles of chemotherapy of "etoposide + cisplatin or carboplatin".Two groups were followed up 5 year and compared with the survival time.Results The 1,3,5 year survival rate of surgery combined with chemotherapy group were 72.97%,35.13%,21.62%.The 1,3,5 year survival rate of control group were 54.05%,13.51%,5.41%.The survival rate of stageⅠ(P = 0.01) was significantly different,but stage Ⅱ(P =0.06) and stage Ⅲ (P = 0.836) were no difference between the two group of SCLC.Conclusion It was found that surgery combined with chemotherapy got satisfactory effects in stage Ⅰ SCLC.