中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2012年
13期
112-114
,共3页
黄有荣%高冠群%杨丽平%陈维武%马渊
黃有榮%高冠群%楊麗平%陳維武%馬淵
황유영%고관군%양려평%진유무%마연
桡骨骨折%骨折愈合%骨形态发生蛋白质类%成纤维细胞生长因子2%白脉软膏
橈骨骨摺%骨摺愈閤%骨形態髮生蛋白質類%成纖維細胞生長因子2%白脈軟膏
뇨골골절%골절유합%골형태발생단백질류%성섬유세포생장인자2%백맥연고
Radius fracture%Fracture healing%Bone morphogenetic proteins%Fibroblast growth factor 2%Baimai recipe
目的 通过观察外用白脉软膏对家兔桡骨骨折愈合过程的影响,研究白脉软膏改善骨伤愈合的作用及其可能的作用机制.方法 机械法建立家兔桡骨骨折动物模型,观察记录实验动物伤腿开始着地及加力着地时间；免疫组化法观察动物骨痂处骨形态发生蛋白2(BMP2)及碱性成纤维细胞生长因子(bFGF)水平.结果 外用白脉软膏对骨折模型动物患肢开始着地时间没有影响,但可明显缩短患肢加力着地时间；白脉软膏中及高剂量均可明显升高模型动物骨痂处BMP2及bFGF水平.结论 外用白脉软膏对骨折模型动物骨伤愈合过程具有明显的促进作用,其促进骨折愈合作用与调节骨痂处BMP2及bFGF水平有关.
目的 通過觀察外用白脈軟膏對傢兔橈骨骨摺愈閤過程的影響,研究白脈軟膏改善骨傷愈閤的作用及其可能的作用機製.方法 機械法建立傢兔橈骨骨摺動物模型,觀察記錄實驗動物傷腿開始著地及加力著地時間；免疫組化法觀察動物骨痂處骨形態髮生蛋白2(BMP2)及堿性成纖維細胞生長因子(bFGF)水平.結果 外用白脈軟膏對骨摺模型動物患肢開始著地時間沒有影響,但可明顯縮短患肢加力著地時間；白脈軟膏中及高劑量均可明顯升高模型動物骨痂處BMP2及bFGF水平.結論 外用白脈軟膏對骨摺模型動物骨傷愈閤過程具有明顯的促進作用,其促進骨摺愈閤作用與調節骨痂處BMP2及bFGF水平有關.
목적 통과관찰외용백맥연고대가토뇨골골절유합과정적영향,연구백맥연고개선골상유합적작용급기가능적작용궤제.방법 궤계법건립가토뇨골골절동물모형,관찰기록실험동물상퇴개시착지급가력착지시간；면역조화법관찰동물골가처골형태발생단백2(BMP2)급감성성섬유세포생장인자(bFGF)수평.결과 외용백맥연고대골절모형동물환지개시착지시간몰유영향,단가명현축단환지가력착지시간；백맥연고중급고제량균가명현승고모형동물골가처BMP2급bFGF수평.결론 외용백맥연고대골절모형동물골상유합과정구유명현적촉진작용,기촉진골절유합작용여조절골가처BMP2급bFGF수평유관.
Objective To investigate the influence of Baimai recipe on the healing progress of fracture.Methods The bone fracture model was established in the right radius of rabbits.The time for step begin and power step begin were recorded,BMP2,bFGF expressions in callus were detected by immunohistochemistry method.Results Without changing the time of step beginning,Baimai recipe treatment could significantly shorten the time of power step beginning.Baimai recipe increased BMP2 and bFGF expression in callus of fracture animal model.Conclusions The study shows that Baimai recipe could facilitate bone healing progress,Baimai recipe may exert its bone healing effects through modulating BMP2 and bFGF expression in callus.
