国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
13期
1859-1861
,共3页
重症手足口病%丙种球蛋白%大剂量
重癥手足口病%丙種毬蛋白%大劑量
중증수족구병%병충구단백%대제량
Severe hand,foot and mouth disease%Gamma-immunoglobulin%High dose
目的 探讨大剂量丙种球蛋白治疗重症手足口病的临床疗效.方法 将115例重症手足口病患儿分为小剂量组(n=57)和大剂量组(n=58).在综合治疗的基础上,小剂量组加用丙种球蛋白0.2 g/( kg·d),静脉点滴2d；大剂最组加用丙种球蛋 白2 g/(kg·d),静脉点滴2d.观察、对比两组患儿的主要症状、辅助检查缓解情况和临床疗效.结果 小剂量组的退热时间和住院时间[(5.2±2.1)d、(13.5±4.3)d]明显比大剂量组[( 3.5±1.8)d、(10.7±3.6)d]((P＜ 0.05)长.出院或转科时,小剂量组的白细胞异常和C反应蛋白的异常病例(7例和5例)明显多于大剂量组(1例和1例)(P＜0.05).小刺量丙种球蛋白治疗重症手足口病的有效率(包括治愈和好转病例)为71.9％,明显低于大剂量组的有效率(91.4％),差异有统计学意义(P＜0.05).结论 大剂量丙种球蛋白能增强重症手足口病患者抵抗病毒的能力,缩短发热时间和住院时间,提高治疗的有效率.
目的 探討大劑量丙種毬蛋白治療重癥手足口病的臨床療效.方法 將115例重癥手足口病患兒分為小劑量組(n=57)和大劑量組(n=58).在綜閤治療的基礎上,小劑量組加用丙種毬蛋白0.2 g/( kg·d),靜脈點滴2d；大劑最組加用丙種毬蛋 白2 g/(kg·d),靜脈點滴2d.觀察、對比兩組患兒的主要癥狀、輔助檢查緩解情況和臨床療效.結果 小劑量組的退熱時間和住院時間[(5.2±2.1)d、(13.5±4.3)d]明顯比大劑量組[( 3.5±1.8)d、(10.7±3.6)d]((P＜ 0.05)長.齣院或轉科時,小劑量組的白細胞異常和C反應蛋白的異常病例(7例和5例)明顯多于大劑量組(1例和1例)(P＜0.05).小刺量丙種毬蛋白治療重癥手足口病的有效率(包括治愈和好轉病例)為71.9％,明顯低于大劑量組的有效率(91.4％),差異有統計學意義(P＜0.05).結論 大劑量丙種毬蛋白能增彊重癥手足口病患者牴抗病毒的能力,縮短髮熱時間和住院時間,提高治療的有效率.
목적 탐토대제량병충구단백치료중증수족구병적림상료효.방법 장115례중증수족구병환인분위소제량조(n=57)화대제량조(n=58).재종합치료적기출상,소제량조가용병충구단백0.2 g/( kg·d),정맥점적2d；대제최조가용병충구단 백2 g/(kg·d),정맥점적2d.관찰、대비량조환인적주요증상、보조검사완해정황화림상료효.결과 소제량조적퇴열시간화주원시간[(5.2±2.1)d、(13.5±4.3)d]명현비대제량조[( 3.5±1.8)d、(10.7±3.6)d]((P＜ 0.05)장.출원혹전과시,소제량조적백세포이상화C반응단백적이상병례(7례화5례)명현다우대제량조(1례화1례)(P＜0.05).소자량병충구단백치료중증수족구병적유효솔(포괄치유화호전병례)위71.9％,명현저우대제량조적유효솔(91.4％),차이유통계학의의(P＜0.05).결론 대제량병충구단백능증강중증수족구병환자저항병독적능력,축단발열시간화주원시간,제고치료적유효솔.
Objective To explore the clinical efficacy high dose gamma-immunoglobulin for severe hand,foot and mouth disease ( HFMD ).Methods One hundred and fifteen children with severe HFMD were randomized to lowdose group ( n =57 ) and high-dose group ( n =58 ).In addition to comprehensive treatment,low-dose group received intravenous gamma-immunoglobulin infusion ( 0.2 g/kg*d ) for 2 days,and high-dose group received gamma-immunoglobulin ( 2 g/kg·d ) for 2 days.The relief of major symptoms and improvement of tests and the efficacy were compared between the two groups.Results The duration of fever and length of hospital stay were significantly longer in the low-dose group than in high-dose group [( 5.2 ± 2.1 ) d vs.( 3.5 ± 1.8 ) d and ( 13.5 ± 4.3 ) d vs.( 10.7 ± 3.6 )d,P＜ 0.05 )].At the time of discharge or transfer,the cases of abnormal leucocytes and C-reaction protein were significantly more in lowdose group than in high-dose group ( 7 vs.1 cases and 5 vs.1 cases,P＜ 0.05 ).The effectiveness rate ( including cured and improved cases ) in low-dose group was significantly lower than that in the high-dose group( 71.9％ vs.91.4％,P＜0.05 ).Conclusions Application of high dose gamma-inmunoglobulin can improve the antiviral effect in children with HFMD,shorten duration of fever and length of hospital stay,and increase the therapeutic effect.
