国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2011年
2期
123-126
,共4页
副肿瘤综合征%风湿性疾病%肿瘤相关抗原%自身抗体
副腫瘤綜閤徵%風濕性疾病%腫瘤相關抗原%自身抗體
부종류종합정%풍습성질병%종류상관항원%자신항체
Paraneoplastic syndromes%Rheumatic diseases%Tumor-associated antigens%Autoantibody
副肿瘤相关性风湿综合征是肿瘤引起的风湿性疾病样的临床表现的总和.由于基础疾病一肿瘤常处于隐匿状态而易与特发性风湿病相混淆,其发病机制包括异位激素分泌,B淋巴细胞恶性转化或自身抗原诱导产生自身抗体以及T细胞调节功能障碍而过量表达细胞因子等.因而研究副肿瘤相关性风湿综合征的定义、流行病学、临床表现、发病机制及临床转归很有意义.
副腫瘤相關性風濕綜閤徵是腫瘤引起的風濕性疾病樣的臨床錶現的總和.由于基礎疾病一腫瘤常處于隱匿狀態而易與特髮性風濕病相混淆,其髮病機製包括異位激素分泌,B淋巴細胞噁性轉化或自身抗原誘導產生自身抗體以及T細胞調節功能障礙而過量錶達細胞因子等.因而研究副腫瘤相關性風濕綜閤徵的定義、流行病學、臨床錶現、髮病機製及臨床轉歸很有意義.
부종류상관성풍습종합정시종류인기적풍습성질병양적림상표현적총화.유우기출질병일종류상처우은닉상태이역여특발성풍습병상혼효,기발병궤제포괄이위격소분비,B림파세포악성전화혹자신항원유도산생자신항체이급T세포조절공능장애이과량표체세포인자등.인이연구부종류상관성풍습종합정적정의、류행병학、림상표현、발병궤제급림상전귀흔유의의.
Paraneoplastic rheumatic syndromes(PRS) are the rheumatic syndromes caused by tumor,which are usually misdiagnosed at beginning as idiopathic rheumatic diseases since the cancer is occult. And as a result of endocrine disorder and aberrant immune responses, the pathogcnesis of PRS involves tumor-derived biologic mediators such as hormones, cytokines, peptides and antibodies. It is important to know that the recent researches about paraneoplastic rheumatic syndromes from the aspects of definition, epidemiology, clinical manifestation, pathogenesis and clinical outcome.
