国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
z1期
10-13
,共4页
蛋白酪氨酸磷酸酶1B%胰岛素信号%瘦素信号%集落刺激因子-1%Ras信号%整合素信号
蛋白酪氨痠燐痠酶1B%胰島素信號%瘦素信號%集落刺激因子-1%Ras信號%整閤素信號
단백락안산린산매1B%이도소신호%수소신호%집락자격인자-1%Ras신호%정합소신호
Protein tyrosine phosphatase 1B%Insulin signaling%Leptin signaling%CSF-1%Ras signaling%Integrin signaling
蛋白酪氨酸磷酸酶-1B(PTP-1B)通过对细胞内不同蛋白底物脱磷酸化参与不同的生理反应,在胰岛素、瘦素等多条细胞信号通路中发挥作用.因其参与多种生理、病理过程,近年来PTP-1B抑制剂的提取和研制成为相关疾病防治的新方向.
蛋白酪氨痠燐痠酶-1B(PTP-1B)通過對細胞內不同蛋白底物脫燐痠化參與不同的生理反應,在胰島素、瘦素等多條細胞信號通路中髮揮作用.因其參與多種生理、病理過程,近年來PTP-1B抑製劑的提取和研製成為相關疾病防治的新方嚮.
단백락안산린산매-1B(PTP-1B)통과대세포내불동단백저물탈린산화삼여불동적생리반응,재이도소、수소등다조세포신호통로중발휘작용.인기삼여다충생리、병리과정,근년래PTP-1B억제제적제취화연제성위상관질병방치적신방향.
Protein tyrosine phosphatase 1B(PTP-1B)dephosphorylates different protein substrates in cells so that different physiological reactions are generated.PTP-1B has been implicated as a regulator of multiple signaling pathways,such as insulin and leptin signaling transduction,and so on.In recent years,as further understanding of the role of PTP-1B in muhiple physiological and pathological reactions,the extraction and advanced development of PTP-1B inhibitors may reveal novel prophylactic and therapeutic strategies in treating related diseases.
