中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2009年
3期
206-208
,共3页
直肠肿瘤/放射疗法%术前放疗%预后
直腸腫瘤/放射療法%術前放療%預後
직장종류/방사요법%술전방료%예후
Rectal cancer/radiotherapy%Preoperative radiotherapy%Prognosis
目的 探讨直肠痛肿瘤组织内术前放疗后浸润淋巴细胞(TIL)数量改变对预后的影响.方法 搜集近8年余接受30 Gy分10次12 d完成的术前放疗的直肠癌患者107例,分析TIL分级与术前放疗后病理消退程度及预后关系.结果 直肠癌放疗前TIL 1级75例,2级16例,3级16例,4级0例,术前放疗后TIL 1级19例,2级43例,3级35例,4级10例.放疗后病理消退分级1级36例,2级57例,3级14例.单因素分析发现放疗前及放疗后TIL对局部病理消退影响有统计学意义(X2=36.80,P<0.01;X2=14.00,P<0.01);术前放疗后癌巢内TIL及病理消退对预后影响显著(X2=24.00,P<0.01;X2=12.17,P<0.01).Logistic多元分析提示放疗后TIL与病理消退关系密切(X2=8.05,P<0.01).结论 放疗前及放疗后TIL与直肠癌术前放疗局部病理消退相关.直肠癌术前放疗后癌巢TIL是影响生存预后的因素之一.
目的 探討直腸痛腫瘤組織內術前放療後浸潤淋巴細胞(TIL)數量改變對預後的影響.方法 搜集近8年餘接受30 Gy分10次12 d完成的術前放療的直腸癌患者107例,分析TIL分級與術前放療後病理消退程度及預後關繫.結果 直腸癌放療前TIL 1級75例,2級16例,3級16例,4級0例,術前放療後TIL 1級19例,2級43例,3級35例,4級10例.放療後病理消退分級1級36例,2級57例,3級14例.單因素分析髮現放療前及放療後TIL對跼部病理消退影響有統計學意義(X2=36.80,P<0.01;X2=14.00,P<0.01);術前放療後癌巢內TIL及病理消退對預後影響顯著(X2=24.00,P<0.01;X2=12.17,P<0.01).Logistic多元分析提示放療後TIL與病理消退關繫密切(X2=8.05,P<0.01).結論 放療前及放療後TIL與直腸癌術前放療跼部病理消退相關.直腸癌術前放療後癌巢TIL是影響生存預後的因素之一.
목적 탐토직장통종류조직내술전방료후침윤림파세포(TIL)수량개변대예후적영향.방법 수집근8년여접수30 Gy분10차12 d완성적술전방료적직장암환자107례,분석TIL분급여술전방료후병리소퇴정도급예후관계.결과 직장암방료전TIL 1급75례,2급16례,3급16례,4급0례,술전방료후TIL 1급19례,2급43례,3급35례,4급10례.방료후병리소퇴분급1급36례,2급57례,3급14례.단인소분석발현방료전급방료후TIL대국부병리소퇴영향유통계학의의(X2=36.80,P<0.01;X2=14.00,P<0.01);술전방료후암소내TIL급병리소퇴대예후영향현저(X2=24.00,P<0.01;X2=12.17,P<0.01).Logistic다원분석제시방료후TIL여병리소퇴관계밀절(X2=8.05,P<0.01).결론 방료전급방료후TIL여직장암술전방료국부병리소퇴상관.직장암술전방료후암소TIL시영향생존예후적인소지일.
Objective To evaluate the effect of tumor infiltrating lymphocyte(TIL) on prognosis of rectal cancer treated with preoperative radiotherapy. Methods From Jan. 1999 to Oct. 2007,107 patients with rectal cancer were treated with preoperative radiotherapy of 30 Gy/10f/12 days. The relationships a-mong TIL,pathologic regression and prognosis were analyzed. Results Before radiotherapy,TIL in rectal cancer was 75 patients (70.1%) in grade 1,16 (15.0%) in grade 2 and 16 (15.0%) in grade 3; While after radiotherapy,it changed to 19 (17.7 %) in grade 1,43 (40.2%) in grade 2,35 (32.7 %) in grade 3 and 10 (9.3%) in grade 4. After radiotherapy,pathologic regression was 36 (33.6%) in grade 1,57 (53.3%) in grade 2 and 14 (13.1%) in grade 3. Univariate analysis showed that TIL both before and after radiotherapy was the significant prognostic factor for local pathologic regression (X2= 36.80, P < 0.01; X<'2>= 14.00, P<0.01). Kaplan Meier survival analysis showed that TIL and pathologic regression after radiother-apy were significant associated with the survival(X2=24.00, P < 0.01; X2=12.17, P<0.01 ). Logistic re-gression showed that TIL after radiotherapy had a significant effect on local pathologic regression(X2=8.05, P<0.01). Conclusions For rectal cancer treated with preoperative radiotherapy,TIL before and after ra-diotherapy is significantly related with local pathologic regression, and TIL after radiotherapy is a prognostic factor.
