CAJ | 학술논문

目的观察微创置管胸腔内灌注顺铂联合全身化疗治疗肺癌患者胸腔积液的疗效及不良反应.方法选取60例肺癌伴胸腔积液患者,应用微创置管胸腔内闭式引流,局部灌注顺铂,并同时全身化疗,非小细胞肺癌用吉西他滨联合顺铂(GP方案)化疗,小细胞肺癌以依托泊苷联合顺铂(EP方案)化疗.结果 60例患者中胸腔积液完全缓解41例,部分缓解13例,稳定4例,进展2例,完全缓解率为68.3％(41/60),总有效率为90.0％(54/60).治疗后患者半年生存率为95.0％ (57/60),1年生存率为80.0％(48/60).局部联合全身化疗的不良反应主要是骨髓抑制和胃肠道反应.结论微创置管胸腔内灌注顺铂联合全身化疗治疗肺癌患者胸腔积液疗效明显,不良反应均可耐受.
목적 관찰미창치관흉강내관주순박연합전신화료치료폐암환자흉강적액적료효급불량반응.방법 선취60례폐암반흉강적액환자,응용미창치관흉강내폐식인류,국부관주순박,병동시전신화료,비소세포폐암용길서타빈연합순박(GP방안)화료,소세포폐암이의탁박감연합순박(EP방안)화료.결과 60례환자중흉강적액완전완해41례,부분완해13례,은정4례,진전2례,완전완해솔위68.3％(41/60),총유효솔위90.0％(54/60).치료후환자반년생존솔위95.0％ (57/60),1년생존솔위80.0％(48/60).국부연합전신화료적불량반응주요시골수억제화위장도반응.결론 미창치관흉강내관주순박연합전신화료치료폐암환자흉강적액료효명현,불량반응균가내수.
Objective To observe the effect and adverse reactions of thoracic cavity drainage with perfusion of cisplatin and combining systemic chemotherapy in lung cancer with malignant pleural effusion.Methods Sixty cases of lung cancer with malignant pleural effusion were treated with thoracic cavity drainage with peffusion of cisplatin and combining systemic chemotherapy.The patients with non-small cell lung cancer were treated with gemcitabine and cisplatin.The patients with small cell lung cancer were treated with etoposide and cisplatin.Results Among the 60 cases,41 cases got complete remission,13 cases got partial remission,4 eases got stable disease and 2cases got progression disease.The complete response rate was 68.3％(41/60) and total curative rate was 90.0％(54/60).After the treatment the half-year survival rate was 95.0％(57/60)and the one-year survival rate was 80.0％(48/60).The main side effects were myelo suppression and gastrointestinal reaction.Conclusions The curative effect is significant through thoracic cavity drainage with perfusion of cisplatin and combining systemic chemotherapy.The adverse effects are tolerable.