CAJ | 학술논문

目的探讨社区老年人轻度认知功能障碍影响因素.方法采用n:m不等比匹配的病例对照研究方法,应用Spss软件中的Cox回归模型进行不等比匹配logistic回归分析.结果最终入选病例423例,对照925名.通过单因素和多因素Cox回归分析,得出轻度认知功能障碍发生危险因素,其OR值及95%C1分别是:从事体力劳动1.396(1.092～1.785),吸烟1.551(1.021～2.359),血清中较高血糖浓度1.354(1.102～1.664),较高HDL-C 1.543(1.232～1.932),较高LDL-C1.299(1.060～1.592),低雌激素水平1.263(1.031～1.547),高血压1.967(1.438～2.689),糖尿病1.381(1.139～1.675),抑郁症1.406(1.110～1.780),脑血栓1.593(1.307～1.943),较高SBP 1.331(1.129～1.569),ApoEε4型等位基因1.462(1.140～1.873);保护因素有:常读书看报0.610(0.503～0.740),常参加公益活动0.617(0.502～0.757),常做家务0.804(0.665～0.973),退休后有第二职业0.759(0.636 0.906),嗅觉敏锐0.900(0.845～0.958),性格外向0.829(0.699～0.984),性格果断0.811(0.662～0.993).结论从事脑力劳动、健康生活方式以及降低糖尿病、高血压、高血糖、高血脂、抑郁症、脑血管病变发生风险是预防老年人轻度认知功能障碍发生的主要手段.
목적 탐토사구노년인경도인지공능장애영향인소.방법 채용n:m불등비필배적병례대조연구방법,응용Spss연건중적Cox회귀모형진행불등비필배logistic회귀분석.결과최종입선병례423례,대조925명.통과단인소화다인소Cox회귀분석,득출경도인지공능장애발생위험인소,기OR치급95%C1분별시:종사체력노동1.396(1.092～1.785),흡연1.551(1.021～2.359),혈청중교고혈당농도1.354(1.102～1.664),교고HDL-C 1.543(1.232～1.932),교고LDL-C1.299(1.060～1.592),저자격소수평1.263(1.031～1.547),고혈압1.967(1.438～2.689),당뇨병1.381(1.139～1.675),억욱증1.406(1.110～1.780),뇌혈전1.593(1.307～1.943),교고SBP 1.331(1.129～1.569),ApoEε4형등위기인1.462(1.140～1.873);보호인소유:상독서간보0.610(0.503～0.740),상삼가공익활동0.617(0.502～0.757),상주가무0.804(0.665～0.973),퇴휴후유제이직업0.759(0.636 0.906),후각민예0.900(0.845～0.958),성격외향0.829(0.699～0.984),성격과단0.811(0.662～0.993).결론종사뇌력노동、건강생활방식이급강저당뇨병、고혈압、고혈당、고혈지、억욱증、뇌혈관병변발생풍험시예방노년인경도인지공능장애발생적주요수단.
Objective To explore the influencing factors on mild cognitive impairment among the community-based elderly population.Methods A‘n:m'matched case-control study was conducted to analyze the risk factors.COx regression model of survival analysis was selected to deal with non-geometric proportional matched data which was difficult to analyze by logistic regression modeI.Results Four hundred and twenty-three cases together with nine hundred and twenty-five controls were interviewed with an uniformed questionnaire.Through univariate and multivariate cox regression analysis,the odds ratio and 95%CJ of these risk factors appeared to be:physieal labor as 1.396(1.092-1.785);smoking as 1.551 (1.021-2.359);higher level of blood glucose as 1.354(1.102-1.664);HDL-C in the serum as 1.543 (1.232-1.932);LDL-C in the serum as 1.299(1.060-1.592);lower level of estrogen in the serum as 1.263(1.031-1.547);hypertension as 1.967(1.438-2.689);diabete:1.381(1.139-1.675);depressive disorder:1.406(1.110-1.780);cerebral thrombosis as 1.593(1.307-1.943);higher SBP as 1.331(1.129-1.569)and ApoEe4 carrier as 1.462(1.140-1.873)respectively.Odds ratio and 95%CI on protection factors appeared to be:reading newspaper frequently as 0.610(0.503-0.740);frequently doing housework as 0.804(0.665-0.973);frequently engaging in social activities as 0.617(0.502-0.757);reemployment after formal retirement as 0.759(0.636-0.906);having acumen olfaction as 0.900(0.845-0.958);having extrovert personality as 0.829(0.699-0.984);being decisive as 0.811(0.662-0.993).Conclusion The major measures to prevent MCI seemed to be including the following factors as:being intellectuals,engaging in healthy life style and decreasing the risk in developing hypertension,diabetes,depressive disorder and cerebrovascular disease.However.olfactory hypoesthesia,cowardice and haring introvert character,ApoEε4 carrier etc could be treated as early indications to signify MCI.