CAJ | 학술논문

目的鉴定MTB北京基因型菌株,了解北京基因型菌株在新疆维吾尔自治区(简称新疆)南疆地区的分布特征,为新疆地区结核病的防治和分子流行病学研究提供科学依据.方法 2009年1-6月,从新疆喀什市、和田市结核病医院和疾病预防控制中心住院及登记结核病拟诊患者的痰液中收集MTB临床分离株,采用RD105缺失基因检测法鉴定北京基因型菌株.用频数和百分率进行统计学描述.结果共收集到200株MTB临床分离株,采用RD105缺失基因检测法对临床分离株进行鉴定,共分为2个基因群,即北京基因型和非北京基因型,其中北京基因型菌株79株,占全部菌株的39.5%(79/200),非北京基因型菌株121株,占全部菌株的60.5%(121/200).结论 MTB北京基因型菌株在新疆南疆地区维吾尔族人群中呈一般流行趋势,北京基因型菌株是否为新疆地区的主要流行菌株还有待进一步研究.
목적 감정MTB북경기인형균주,료해북경기인형균주재신강유오이자치구(간칭신강)남강지구적분포특정,위신강지구결핵병적방치화분자류행병학연구제공과학의거.방법 2009년1-6월,종신강객십시、화전시결핵병의원화질병예방공제중심주원급등기결핵병의진환자적담액중수집MTB림상분리주,채용RD105결실기인검측법감정북경기인형균주.용빈수화백분솔진행통계학묘술.결과 공수집도200주MTB림상분리주,채용RD105결실기인검측법대림상분리주진행감정,공분위2개기인군,즉북경기인형화비북경기인형,기중북경기인형균주79주,점전부균주적39.5%(79/200),비북경기인형균주121주,점전부균주적60.5%(121/200).결론 MTB북경기인형균주재신강남강지구유오이족인군중정일반류행추세,북경기인형균주시부위신강지구적주요류행균주환유대진일보연구.
Objective To identify the Beijing family strain of Mycobacterium tuberculosis (M.tuberculosis) in order to find out the distribution of the Beijing family strain in the south region of Xinjiang,and therefore to provide scientific basis for the prevention and treatment of tuberculosis and the study of molecular epidemiology. Methods From Kashi and Hetian Pulmonary Hospitals and Centers for Disease Control and Prevention, the M. tuberculosis strain were collected and isolated from the sputum of inpatients and registered cases infected with M. tuberculosis, from January to June of 2009. The Beijing family strain was identified by RD105 deletion test. The statistical description was performed using frequency and percentage. Results A total of 200 clinical isolates of M. tuberculosis was collected. By means of RD105 deletion test, these strains were typed into 2 groups: the Beijing family and the non-Beijing family. Seventynine strains belonged to the Beijing family (79/200, 39. 5% ) and 121 strains to the non-Beijing family (121/200, 60.5% ). Conclusion M. tuberculosis of the Beijing family strain is prevalent at a common level in Uygur living in the south region of Xinjiang. It needs to be investigated whether the Beijing family strain of M. tuberculosis is the predominant strain in the whole region.