CAJ | 학술논문

糖尿病肾病(DN)是糖尿病重要的微血管并发症之一,其发病机制是多种因素共同作用的结果.近年来发现Rho/Rho激酶(Rho/ROCK)信号通路与多种组织重构如血管、心肌、肾纤维化等相关.高糖能够刺激肾脏细胞内Rho/ROCK信号通路的激活,后者通过调控转录因子的DNA结合活性上调多种基因的表达,从而引起各种炎性反应及肾小球纤维化,而应用此信号通路选择性抑制剂后可明显改善DN的发生和发展,从而认为Rho/ROCK信号转导通路可能在DN的发病机制中起关键作用.
당뇨병신병(DN)시당뇨병중요적미혈관병발증지일,기발병궤제시다충인소공동작용적결과.근년래발현Rho/Rho격매(Rho/ROCK)신호통로여다충조직중구여혈관、심기、신섬유화등상관.고당능구자격신장세포내Rho/ROCK신호통로적격활,후자통과조공전록인자적DNA결합활성상조다충기인적표체,종이인기각충염성반응급신소구섬유화,이응용차신호통로선택성억제제후가명현개선DN적발생화발전,종이인위Rho/ROCK신호전도통로가능재DN적발병궤제중기관건작용.
Diabetic nephropathy(DN)is one of the important microvascular complications of diabetes mellitus,the pathogenesis of DN is complex,currently considered to be the result of many factors.Recently,several researches have found that Rho/ROCK signaling pathway was related to reconstruction of organization,such as vascular,myocardium,renal fibrosis and so on.Hyperglycemia can stimulate activation of Rho/ROCK signaling pathway in renal cells,the latter could raise several genes'expression through regulating activity of transcription factor binding to DNA,thereby causing inflammation and glomerular fibrosis.Accordingly,application of selective inhibitors of this pathway Can significantly improve the occurrence and development of DN.Accumulating evidence suggested that activation of the Rho/ROCK signaling pathway has a prominent role in the pathogenesis of DN.