CAJ | 학술논문

目的观察冠心宁注射液对老年心力衰竭(CHF)患者氧自由基的影响.方法 58例CHF患者,随机分为常规治疗组和冠心宁治疗组各29例,选取32例健康体检者作为对照.冠心宁组在常规治疗基础上加用冠心宁注射液治疗14 d,观察其血浆中丙二醛(MDA)、血清总抗氧能力(TAOC)、氧化型低密度脂蛋白胆固醇(OX-LDL-C)、血清超氧化物歧化酶(SOD)的变化.结果 58例CHF患者血清MDA[(5.59±1.95)μmol/L]和OX-LDL-C[(808.64±156.34)μg/L]水平明显高于时照组[(4.04±0.67)μmol/L与(538.67±125.43)μg/L](P<0.05),SOD[(68.69±20.43)μU/L]、TAOC[(7.72±2.13)kU/L]显著低于对照组[(105.67±13.86)μU/L与(9.68±1.86)kU/L](P<0.05),心功能Ⅱ、Ⅲ、Ⅳ级CHF患者SOD、MDA、OX-LDL-C和TAOC差异均有统计学意义(F分别为18.86、10.63、25.57和11.27,P均<0.05).治疗14 d冠心宁组有效率为96.6%(28/29),高于常规治疗组(79.3%,23/29),差异有统计学意义(X2=6.41,P<0.05).结论冠心宁对CHF患者的治疗作用可能与其促进机体氧自由基的清除有关.
목적 관찰관심저주사액대노년심력쇠갈(CHF)환자양자유기적영향.방법 58례CHF환자,수궤분위상규치료조화관심저치료조각29례,선취32례건강체검자작위대조.관심저조재상규치료기출상가용관심저주사액치료14 d,관찰기혈장중병이철(MDA)、혈청총항양능력(TAOC)、양화형저밀도지단백담고순(OX-LDL-C)、혈청초양화물기화매(SOD)적변화.결과 58례CHF환자혈청MDA[(5.59±1.95)μmol/L]화OX-LDL-C[(808.64±156.34)μg/L]수평명현고우시조조[(4.04±0.67)μmol/L여(538.67±125.43)μg/L](P<0.05),SOD[(68.69±20.43)μU/L]、TAOC[(7.72±2.13)kU/L]현저저우대조조[(105.67±13.86)μU/L여(9.68±1.86)kU/L](P<0.05),심공능Ⅱ、Ⅲ、Ⅳ급CHF환자SOD、MDA、OX-LDL-C화TAOC차이균유통계학의의(F분별위18.86、10.63、25.57화11.27,P균<0.05).치료14 d관심저조유효솔위96.6%(28/29),고우상규치료조(79.3%,23/29),차이유통계학의의(X2=6.41,P<0.05).결론 관심저대CHF환자적치료작용가능여기촉진궤체양자유기적청제유관.
Objective To investigate the effect of perhexiline injection on oxygen free radical in old patients with heart failure(CHF). Methods 32 healthy parsons were taken as controls. 58 old patients with CHF were ran-domly divided into two groups. The treatment group received both basic therapy and perhexiline injection transfusion for 14 days. Malondialdehyde (MDA) ,total antioxygen capacity(TAOC) ,oxidation-low-density-lipoprotein-cholester-ol (OX-LDL-C) and superoxide dismutase(SOD) were measured before the therapy and after the therapy. Results MDA [ (5.59±1.95 )μmol/L and OX-LDL-C [ ( 808.64 ± 156.34) μg/L] were significantly higher in the old patients with CHF] than control group [ (4.04 ± 0.67 μmol/L ) and ( 538.67 ± 125.43 ) μ/L ] ( P < 0.05 ) ; SOD [ (68.69 ± 20.43 )μU/L ] and TAOC [ ( 7.72±2.13 ) kU/L ] were significantly lower in the old patients with heart failure than the matched group [(105.67±13.86 )μU/L and (9.68±1.86 ) kU/L ] ( P <0.05 ), which were posi-tively associated with CHF severity. After the improvement of the cardiac function, MDA, OX-LDL-C;SOD and TAOC recovered significantly. Conclusion The therapeutic action of perhexiline injection in old patients with CHF can re-ly on the promotion of eliminating oxygen free radical inside organism.