中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
3期
231-233
,共3页
崔松勤%吴晓丽%姚维娜%马正良%顾小萍
崔鬆勤%吳曉麗%姚維娜%馬正良%顧小萍
최송근%오효려%요유나%마정량%고소평
右美托咪定%瑞芬太尼%痛觉过敏%切口痛%大鼠
右美託咪定%瑞芬太尼%痛覺過敏%切口痛%大鼠
우미탁미정%서분태니%통각과민%절구통%대서
Dexmedetomidine%Remifentanil%Hyperalgesia%Incisional pain%Rat
目的 研究大鼠切口痛模型中右美托咪定(DEX)对瑞芬太尼诱发的痛觉过敏的影响.方法 60只雄性SD大鼠随机均分成5组:对照组(C),切口痛组(I),切口痛+瑞芬太尼组(R),切口痛+DEX组(ID),切口痛+瑞芬太尼十DEX组(RD).ID、RD组于七氟醚麻醉前10min腹部皮下注射DEX50 μg/kg.除C组外均需制作切口痛模型.切口痛制作方法:右后爪跖肌位置纵行切开1 cm长的皮肤和筋膜,皮肤行褥式缝合.各组均测定并计算出术前24h(T0),术后6h(T),24h(T2),48h(T3)大鼠右后爪的机械缩足反射阈值(PMW)及热缩足反射阈值(PWTL).结果 在T1、T2、T3时点,与I组[(7.70±0.67)g,(10.79±1.83)g,(10.97±1.87)g]相比,R组[(3.72±0.71)g,(6.54±1.27)g,(7.27±1.53)g]的PMW明显降低(P＜0.05);与Ⅰ组[(20.74±2.72)s,(16.56±1.38)s,(22.55±2.01)s]相比,R组[(11.81±2.52)s,(11.27±2.30)s,(12.30±2.21)s]的PWTL明显降低(P＜0.05).与Ⅰ组相比,ID组只能缓解T1时点PMW的降低(P＜0.05).与R组相比,RD组可以缓解T1[(14.03±1.01)g]、12[(14.27±1.33)g]、T3(14.26±1.58)g]时点的PMW值的降低(P＜0.05)及T1[(23.56±1.53)s]、T2[(16.54±3.24)s]时点的PWTL值的降低(P＜0.05).结论 大鼠切口痛模型中,瑞芬太尼可以诱发切口周围组织的痛觉过敏;右美托咪定可以预防瑞芬太尼诱发的痛觉过敏.
目的 研究大鼠切口痛模型中右美託咪定(DEX)對瑞芬太尼誘髮的痛覺過敏的影響.方法 60隻雄性SD大鼠隨機均分成5組:對照組(C),切口痛組(I),切口痛+瑞芬太尼組(R),切口痛+DEX組(ID),切口痛+瑞芬太尼十DEX組(RD).ID、RD組于七氟醚痳醉前10min腹部皮下註射DEX50 μg/kg.除C組外均需製作切口痛模型.切口痛製作方法:右後爪蹠肌位置縱行切開1 cm長的皮膚和觔膜,皮膚行褥式縫閤.各組均測定併計算齣術前24h(T0),術後6h(T),24h(T2),48h(T3)大鼠右後爪的機械縮足反射閾值(PMW)及熱縮足反射閾值(PWTL).結果 在T1、T2、T3時點,與I組[(7.70±0.67)g,(10.79±1.83)g,(10.97±1.87)g]相比,R組[(3.72±0.71)g,(6.54±1.27)g,(7.27±1.53)g]的PMW明顯降低(P＜0.05);與Ⅰ組[(20.74±2.72)s,(16.56±1.38)s,(22.55±2.01)s]相比,R組[(11.81±2.52)s,(11.27±2.30)s,(12.30±2.21)s]的PWTL明顯降低(P＜0.05).與Ⅰ組相比,ID組隻能緩解T1時點PMW的降低(P＜0.05).與R組相比,RD組可以緩解T1[(14.03±1.01)g]、12[(14.27±1.33)g]、T3(14.26±1.58)g]時點的PMW值的降低(P＜0.05)及T1[(23.56±1.53)s]、T2[(16.54±3.24)s]時點的PWTL值的降低(P＜0.05).結論 大鼠切口痛模型中,瑞芬太尼可以誘髮切口週圍組織的痛覺過敏;右美託咪定可以預防瑞芬太尼誘髮的痛覺過敏.
목적 연구대서절구통모형중우미탁미정(DEX)대서분태니유발적통각과민적영향.방법 60지웅성SD대서수궤균분성5조:대조조(C),절구통조(I),절구통+서분태니조(R),절구통+DEX조(ID),절구통+서분태니십DEX조(RD).ID、RD조우칠불미마취전10min복부피하주사DEX50 μg/kg.제C조외균수제작절구통모형.절구통제작방법:우후조척기위치종행절개1 cm장적피부화근막,피부행욕식봉합.각조균측정병계산출술전24h(T0),술후6h(T),24h(T2),48h(T3)대서우후조적궤계축족반사역치(PMW)급열축족반사역치(PWTL).결과 재T1、T2、T3시점,여I조[(7.70±0.67)g,(10.79±1.83)g,(10.97±1.87)g]상비,R조[(3.72±0.71)g,(6.54±1.27)g,(7.27±1.53)g]적PMW명현강저(P＜0.05);여Ⅰ조[(20.74±2.72)s,(16.56±1.38)s,(22.55±2.01)s]상비,R조[(11.81±2.52)s,(11.27±2.30)s,(12.30±2.21)s]적PWTL명현강저(P＜0.05).여Ⅰ조상비,ID조지능완해T1시점PMW적강저(P＜0.05).여R조상비,RD조가이완해T1[(14.03±1.01)g]、12[(14.27±1.33)g]、T3(14.26±1.58)g]시점적PMW치적강저(P＜0.05)급T1[(23.56±1.53)s]、T2[(16.54±3.24)s]시점적PWTL치적강저(P＜0.05).결론 대서절구통모형중,서분태니가이유발절구주위조직적통각과민;우미탁미정가이예방서분태니유발적통각과민.
Objective To observe the effects of pretreatment of dexmedetomidine(DEX)on remifentanilinduced hyperalgesia in a rat model of incisional pain.Methods Sixty male SD rats were randomly divided into five groups:C group(control),I group(incisional pain),R group(remifentanil+incisional pain),ID group(incisional pain+DEX),RD group(remifentanil+incisional pain+DEX).ID and RD group were administered subcutaneously DEX 50μg/kg at ten minutes before anesthesia with sevoflurane.All groups except C group needed to be made the model of incisional pain.A 1 cm long incision was made through skin and fascia of the plantar aspect of the foot.The skin was apposed with 2 mattress sutures.At 24 hours before operation(T0),6 hours(T1),24 hours(T2)and 48 hours(T3)after operation respectively.Paw Withdrawal Thermal latency(PWTL)and Paw Mechanical Withdrawal Threshold(PMW)were detected on the rats' right hind paw in all groups.Results At T1,T2,T3,compared with I group((7.70±0.67)g,(10.79±1.83)g,(10.97±1.87)g),the PMW of R group ((3.72±0.71)g,(6.54±1.27)g,(7.27±1.53)g)were significantly longer(P＜0.05);compared with I group((20.74±2.72)s,(16.56±1.38)s,(22.55±2.01)s),the PWTL of R group((11.81±2.52)s,(11.27 ±2.30)s,(12.30±2.21)s)were significantly longer(P＜0.05).Compared with I group,the PMW of ID group were only significantly longer(P＜0.05)at T1((11.57±2.48)g).Compared with R group,the PMW of RD group were significantly longer at T1((14.03±1.01)g),T2((14.27±1.33)g),T3((14.26±1.58)g)(P＜0.05)and the PWTL of RD group were significantly longer at T1((23.56±1.53)s),T2((16.54±3.24)s)(P＜0.05).Conclusion In a rat model of incisional pain,remifentanil could induce hyperalgesia,and dexmedetomidine could prevent the remifentanil-induced hyperalgesia.
