CAJ | 학술논문

[目的]探讨重组人脑利钠肽(rhBNP)治疗急性心力衰竭的疗效和安全性.[方法]将48例急性心力衰竭患者随机分为两组:rhBNP组(n=24)以rhBNP静脉推注1.5μg/kg,再以0.0075～0.01 μg/( kg·min)持续泵入3d;对照组(n=22)泵入硝普钠,起始剂量为5μg/min,根据血压调速,每次增加5μg/min,直至达临床效应,持续用3d.记录两组患者治疗前后的全身状况、心脏超声学指标及临床疗效；记录两组患者的不良反应及不良心血管事件.[结果]治疗3d后,rhBNP组临床疗效、心率和尿量优于对照组(P＜0.05)；rhBNP组治疗后心脏指数、舒张功能指标较对照组改善(P＜0.05).在药物的不良反应方面两组比较差异无统计学意义(P＜0.05).[结论]rhBNP治疗急性心力衰竭的临床疗效显著,可明显改善心脏收缩、舒张功能,治疗安全可靠.
[목적]탐토중조인뇌리납태(rhBNP)치료급성심력쇠갈적료효화안전성.[방법]장48례급성심력쇠갈환자수궤분위량조:rhBNP조(n=24)이rhBNP정맥추주1.5μg/kg,재이0.0075～0.01 μg/( kg·min)지속빙입3d;대조조(n=22)빙입초보납,기시제량위5μg/min,근거혈압조속,매차증가5μg/min,직지체림상효응,지속용3d.기록량조환자치료전후적전신상황、심장초성학지표급림상료효；기록량조환자적불량반응급불양심혈관사건.[결과]치료3d후,rhBNP조림상료효、심솔화뇨량우우대조조(P＜0.05)；rhBNP조치료후심장지수、서장공능지표교대조조개선(P＜0.05).재약물적불량반응방면량조비교차이무통계학의의(P＜0.05).[결론]rhBNP치료급성심력쇠갈적림상료효현저,가명현개선심장수축、서장공능,치료안전가고.
[Objective]To investigate the efficacy and safety of recombinant hunan brain natriuretic peptide(rhBNP) in the treatment of acrte heart failure.[Methods]Forty-eight patients with acute heart failure were randomly divided into rhBNP group and control group.Patients in rhBNP group received rhBNP [1.5μg/kg intravenous infusion followed by 0.0075～0.01μg/(kg·min) for 3 days,n =24],and patients in control group received nitroprusside (starting at 5μg/min and increasing 5μg/min each time till clinical effective dose for 3 days,n =22).The clinical effectiveness,general physical condition,parameters of heart function examined by echocardiography were recorded before and after treatment in the two groups.The adverse drug reactions and adverse cardiovascular events were recorded.[Results]The clinical effect,heart rate and urine output were better in rhBNP group than those in control group after 3 days treatment(P＜0.05).The indexes of left ventricular contraction and relaxation ftnctions in rhBNP group were higher than those in control group after treatment(P＜0.05).There was no significant difference in the adverse durg reactions between the two groups (P＜0.05).[Conclusions]Intravenous infusion of rhBNP is effective and safe for acute heart failure patients.It can obviously improve the heart systolic and diastolic fumctioNS.