中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
38期
2682-2685
,共4页
张俐花%周永宁%张志镒%张富花%李高忠%李强%吴正奇%任宝龙%邹绍静%王娟霞
張俐花%週永寧%張誌鎰%張富花%李高忠%李彊%吳正奇%任寶龍%鄒紹靜%王娟霞
장리화%주영저%장지일%장부화%리고충%리강%오정기%임보룡%추소정%왕연하
螺杆菌%幽门%横断面研究%家庭聚集
螺桿菌%幽門%橫斷麵研究%傢庭聚集
라간균%유문%횡단면연구%가정취집
Helicobacter pylori%Cross-sectional studies%Family clustering
目的 对胃癌高发区甘肃省武威市儿童和青少年幽门螺杆菌(Hp)感染状况进行横断面调查.方法 采用随机抽样方法对武威市938名3～18岁儿童和青少年以及96户家庭进行Hp粪便抗原检测;采用Hp蛋白质印迹法对经Hp粪便抗原枪测阳性的80名儿童和青少年进行Hp毒力蛋白分析.结果 武威市儿童及青少年Hp感染率为72.3%(678/938),Hp感染率各年龄组差异无统计学意义.Hp感染可能与居住地区、父母职业、饮水来源、是否上过幼儿园、是否生吃蔬菜、是否刷牙及断奶时间相关.多因素回归分析提示,饮水来源、上过幼儿园、生吃蔬菜是Hp感染的危险因素.Hp阳性标引者家庭其他成员Hp感染率82.3%(121/147)显著高于Hp阴性标引者家庭其他成员的Hp感染率47.4%(18/38)(X~2=19.736 P＜0.05).Ⅰ型Hp感染率为71.3%(57/80),Ⅱ型Hp感染率为28.7%(23/80).结论 武威市儿童和青少年具有较高的Hp感染率,Hp感染存在家庭聚集现象,武威市儿童及青少年Hp感染以Ⅰ型感染为主.
目的 對胃癌高髮區甘肅省武威市兒童和青少年幽門螺桿菌(Hp)感染狀況進行橫斷麵調查.方法 採用隨機抽樣方法對武威市938名3～18歲兒童和青少年以及96戶傢庭進行Hp糞便抗原檢測;採用Hp蛋白質印跡法對經Hp糞便抗原鎗測暘性的80名兒童和青少年進行Hp毒力蛋白分析.結果 武威市兒童及青少年Hp感染率為72.3%(678/938),Hp感染率各年齡組差異無統計學意義.Hp感染可能與居住地區、父母職業、飲水來源、是否上過幼兒園、是否生喫蔬菜、是否刷牙及斷奶時間相關.多因素迴歸分析提示,飲水來源、上過幼兒園、生喫蔬菜是Hp感染的危險因素.Hp暘性標引者傢庭其他成員Hp感染率82.3%(121/147)顯著高于Hp陰性標引者傢庭其他成員的Hp感染率47.4%(18/38)(X~2=19.736 P＜0.05).Ⅰ型Hp感染率為71.3%(57/80),Ⅱ型Hp感染率為28.7%(23/80).結論 武威市兒童和青少年具有較高的Hp感染率,Hp感染存在傢庭聚集現象,武威市兒童及青少年Hp感染以Ⅰ型感染為主.
목적 대위암고발구감숙성무위시인동화청소년유문라간균(Hp)감염상황진행횡단면조사.방법 채용수궤추양방법대무위시938명3～18세인동화청소년이급96호가정진행Hp분편항원검측;채용Hp단백질인적법대경Hp분편항원창측양성적80명인동화청소년진행Hp독력단백분석.결과 무위시인동급청소년Hp감염솔위72.3%(678/938),Hp감염솔각년령조차이무통계학의의.Hp감염가능여거주지구、부모직업、음수래원、시부상과유인완、시부생흘소채、시부쇄아급단내시간상관.다인소회귀분석제시,음수래원、상과유인완、생흘소채시Hp감염적위험인소.Hp양성표인자가정기타성원Hp감염솔82.3%(121/147)현저고우Hp음성표인자가정기타성원적Hp감염솔47.4%(18/38)(X~2=19.736 P＜0.05).Ⅰ형Hp감염솔위71.3%(57/80),Ⅱ형Hp감염솔위28.7%(23/80).결론 무위시인동화청소년구유교고적Hp감염솔,Hp감염존재가정취집현상,무위시인동급청소년Hp감염이Ⅰ형감염위주.
Objective To investigate the prevalence of Helicobacter pylori(Hp)infection among children aged 3 to 18 years old of Wuwei city, Gansu province. Methods The study was hased upon a personal questionnaire and a determination of Hp antigen using the Hp stool antigen test(HpSA)method. A total of 938 subjects and 96 families were selected in Wuwei city. Eighty children and teenagers with a definite positive Hp Mool antigen test were examined by serum Western blotting method. Results The prevalence of Hp was 72.3%(678/938)with no age difference. Prevalence of Hp infection was correlated with type of dwelling, occupation of parents, drinking water source, kindergarten attendance, consumption of raw vegetables, a poor oral hygiene and breast feeding etc. According to the multivariate analysis, drinking water source, kindergarten attendance and consumption of raw vegetables were most strongly associated with prevalence of Hp in children and adolescents. The infection rate of parents whose children were infected with Hp was higher than that of those whose children were not infected[82.3%(121/147)vs 47.4%(18/38), X~2=19.736, P＜0.05). The antibody responses of 57 samples(71.3%)from 80 children were of type ⅠHp and 23 samples(28.7%)type Ⅱ. Conclusions Hp infective rate is high in Wuwei city. The data support maternal-child and sibling-sibling transmission as the primary transmission routes of Hp. The results of serological analysis confirm that the majority of Wuwei Hp infection is of type Ⅰ.
