CAJ | 학술논문

目的比较胃、食管高级别上皮内瘤变病灶内镜活检与内镜切除标本病理诊断的异同.方法选取近4年间147例内镜活检诊断为胃、食管黏膜高级别上皮内瘤变、经内镜下切除(EMR或ESD)患者的资料,对切除前后的病理结果进行对照分析.结果 147例患者活检病理均诊断胃、食管上皮内瘤变,其中胃41例,食管106例;内镜术后97例(66%)维持上皮内瘤变诊断,50例(34%)诊断为癌,且有11例已经侵犯到黏膜下层.病理分型腺癌34例,鳞癌16例,其中低-中分化癌22例(44%).结论内镜活检诊断胃、食管高级别上皮内瘤变的病例超过三分之一已经癌变,应该采取积极的治疗措施.
목적 비교위、식관고급별상피내류변병조내경활검여내경절제표본병리진단적이동.방법 선취근4년간147례내경활검진단위위、식관점막고급별상피내류변、경내경하절제(EMR혹ESD)환자적자료,대절제전후적병리결과진행대조분석.결과 147례환자활검병리균진단위、식관상피내류변,기중위41례,식관106례;내경술후97례(66%)유지상피내류변진단,50례(34%)진단위암,차유11례이경침범도점막하층.병리분형선암34례,린암16례,기중저-중분화암22례(44%).결론 내경활검진단위、식관고급별상피내류변적병례초과삼분지일이경암변,응해채취적겁적치료조시.
Objective To investigate the pathological features of gastro-esophageal high-grade intraepithelial neoplasia (HGIEN) confirmed by biopsy and to compare the differences of its diagnosis after endoscopic resection. Methods Data of 147 patients with gastro-esophageal HGIEN confirmed by biopsy, who underwent EMR or ESD in recent 4 years were analyzed for the pathological findings of pre- and post- procedures. Results Among 147 cases of HGIEN diagnosed by endoscopic biopsy, 106 lesions were in esophagus and 41 in stomach. After endoscopic resection, intraepithelial neoplasia was confirmed in 97 (66%), and cancer was diagnosed in 50 (34%), of which submucosal layer was involved in 11. There were 34 cases of adenocarcinoma and 16 squamous cell carcinomas, in which 22 cases (44%) were poorly or moderately differentiated. Conclusion More than one third cases of biopsy diagnosed HGIEN are confirmed to be carcinoma after endoscopic resection, which needs active therapeutic measures.