CAJ | 학술논문

目的探讨内外源性β-葡萄糖醛酸酶(β-G)与原发性胆总管结石的关系.方法应用改良Fishman法检测35例原发性胆总管结石患者(试验组)和11例胆囊息肉患者(对照组)胆总管内胆汁中内外源性β-G活性.结果试验组和对照组手术当天胆汁中内源性β-G活性分别为(7859.1±738.5)、(2174.9±348.4)U/L(P＜0.01);外源性β-G活性分别为(6786.1±544.3)、(1504.7±655.7)U/L(P＜0.01);试验组中13例急性患者手术当天与术后第7天胆汁中外源性β-G活性分别为(8935.7±845.9)、(2176.1±956.7)U/L(P＜0.05);22例慢性患者分别为(5137.2±540.7)、(1838.8±733.3)U/L(P＜0.05);急性患者手术当天胆汁中外源性β-G活性明显高于慢性患者(P＜0.05).结论内、外源性β-G参与原发性胆总管结石的形成.
목적 탐토내외원성β-포도당철산매(β-G)여원발성담총관결석적관계.방법 응용개량Fishman법검측35례원발성담총관결석환자(시험조)화11례담낭식육환자(대조조)담총관내담즙중내외원성β-G활성.결과 시험조화대조조수술당천담즙중내원성β-G활성분별위(7859.1±738.5)、(2174.9±348.4)U/L(P＜0.01);외원성β-G활성분별위(6786.1±544.3)、(1504.7±655.7)U/L(P＜0.01);시험조중13례급성환자수술당천여술후제7천담즙중외원성β-G활성분별위(8935.7±845.9)、(2176.1±956.7)U/L(P＜0.05);22례만성환자분별위(5137.2±540.7)、(1838.8±733.3)U/L(P＜0.05);급성환자수술당천담즙중외원성β-G활성명현고우만성환자(P＜0.05).결론 내、외원성β-G삼여원발성담총관결석적형성.
Objective To explore the role of endogenous and exogenous β-glucuronidase( β-G) in the development of primary common duct stones.Method Using modified Fishman method to test the activities of the endogenous and exogenous β -G in 35 patients with primary common duct stones(experimental group) and 11 patients with cystic polypus (control group) respectively.Results The activities of endogenous β -G in the bile of experimental group and control group were (7859.1 ± 738.5 ),(2174.9 ± 348.4 ) U/L(P ＜0.01).While the activities of exogenous β-G in experimental group and control group were (6786.1 ±544.3),(1504.7 ±655.7) U/L (P ＜0.01).In experimental group,there were significant statistical differences in the activities of the exogenous β -G in the sample obtained on the day of operation and 7 days after operation from 13 cases with the acute inflammation [(8935.7 ± 845.9),(2176.1 ± 956.7) U/L]and from 22 cases with the chronic inflammation [(5137.2 ±540.7),(1838.8 ±733.3) U/L],and there were significant higher in the activities of the exogenous β -G in the sample obtained on the day of operation from the acute inflammation compared to those from the chronic inflammation (P ＜ 0.05 ).Conclusions There is obvious correlation between either endogenous or exogenous β -G with primary common duct stones.And the endogenous β -G might be one of the fundamental cause in the development of primary common duct stones.c inflammation (P ＜