CAJ | 학술논문

原癌基因的激活是包括肺癌在内的众多恶性肿瘤的重要特征,而原癌基因发生扩增被认为在原癌基因激活过程中起着重要作用.随着分子遗传学技术的发展,人们在实体瘤中发现越来越多的原癌基因存在着扩增现象,因此了解基因扩增可以为肿瘤早期诊断或治疗提供新的有效的靶点.本文综述了目前肺癌中基因扩增的研究进展.
원암기인적격활시포괄폐암재내적음다악성종류적중요특정,이원암기인발생확증피인위재원암기인격활과정중기착중요작용.수착분자유전학기술적발전,인문재실체류중발현월래월다적원암기인존재착확증현상,인차료해기인확증가이위종류조기진단혹치료제공신적유효적파점.본문종술료목전폐암중기인확증적연구진전.
The activation of oncogenes is the key to cancer development, and DNA amplification is known as the major event in oncogene activation. To date, with advances in cytogenetic technique, the amplification of oncogenes has been extensively quantified in all major tumor types. The molecular characterization of oncogene amplifications could lead to early diagnosis and early treatment of cancers that targets a specific genetic abnormality. Our review will focus on the oncogene amplifications in lung cancer.