CAJ | 학술논문

血红素加氧酶-1(heme oxygenase,HO-1)是机体血红素降解过程的限速酶,它可将血红素分解为一氧化碳(CO)、游离铁和胆绿素.目前HO-1及其降解血红素的代谢产物体系在抗氧化、抗凋亡、抗炎症、舒张血管及细胞保护等方面的作用受到了普遍关注.HO-1在器官移植中的作用已成为研究热点,现就HO-1在器官移植中细胞保护作用的研究进展作如下综述.
혈홍소가양매-1(heme oxygenase,HO-1)시궤체혈홍소강해과정적한속매,타가장혈홍소분해위일양화탄(CO)、유리철화담록소.목전HO-1급기강해혈홍소적대사산물체계재항양화、항조망、항염증、서장혈관급세포보호등방면적작용수도료보편관주.HO-1재기관이식중적작용이성위연구열점,현취HO-1재기관이식중세포보호작용적연구진전작여하종술.
Heme oxygenase is the rate-limiting enzyme in the catabolism of heme, a process that leads to formation of equimolar amounts of the bile pigment biliverdin, free iron, and carbon monoxide (CO). Nowadays HO-1 and heme metabolic products have following features: anti -oxidation, anti -inflammation, anti-apoptosis, down regulation the expression of blood vessel endothelium adhesion molecule and decreasing the injury of blood vessel and increasing transplanted organs blood, dilating blood vessel and cytoprotection. All the features have abstracted more and more attentions. The role of HO-1 in organ transplantation also become the core of investigation. Here, we will take a review in the role of HO-1 in organ transplantation.