白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2011年
6期
382-384
,共3页
多发性骨髓瘤%骨病医学%细胞因子类%靶向治疗
多髮性骨髓瘤%骨病醫學%細胞因子類%靶嚮治療
다발성골수류%골병의학%세포인자류%파향치료
Multiple myeloma%Osteopathic medicine%Cytokines%Targeted therapy
多发性骨髓瘤(MM)是血液系统恶件肿瘤,骨破坏是其最常见的并发症,骨相关事件严重影响MM患者的生活质量及预后.目前对于骨髓瘤骨病(MBD)的治疗原则仍以双膦酸盐类药物为主.近年来对MBD发病机制的认识及治疗均取得了新进展.现就目前已知参与MBD发病机制的重要细胞因子及靶向治疗相关进展进行综述.
多髮性骨髓瘤(MM)是血液繫統噁件腫瘤,骨破壞是其最常見的併髮癥,骨相關事件嚴重影響MM患者的生活質量及預後.目前對于骨髓瘤骨病(MBD)的治療原則仍以雙膦痠鹽類藥物為主.近年來對MBD髮病機製的認識及治療均取得瞭新進展.現就目前已知參與MBD髮病機製的重要細胞因子及靶嚮治療相關進展進行綜述.
다발성골수류(MM)시혈액계통악건종류,골파배시기최상견적병발증,골상관사건엄중영향MM환자적생활질량급예후.목전대우골수류골병(MBD)적치료원칙잉이쌍련산염류약물위주.근년래대MBD발병궤제적인식급치료균취득료신진전.현취목전이지삼여MBD발병궤제적중요세포인자급파향치료상관진전진행종술.
Multiple myeloma (MM) is a hematological malignancy. Osteolytic lesion is the commonest complication in patients with MM. Skeletal-related events severely affect the survival quantity and prognosis. Current therapeutic approach for the treatment of myeloma bone disease (MBD) is based on the use of bisphosphonates. AS the recent advance in the pathogenesis and therapeutics of MBD,more factors related to this disease are found. In this article important factors related to the pathogenes of MBD and the cytokine targeted therapies are reviewed.
