CAJ | 학술논문

目的探讨氢氯吡格雷与辛伐他汀联合治疗急性冠脉综合征(ACS)的临床效果.方法将2007年1月-2009年5月间在我院治疗的ACS患者64例随机分为观察组和对照组,对照组给予常规治疗措施,观察组同时给予氢氯吡格雷与辛伐他汀联合治疗措施.结果两组患者血小板聚集率比较:治疗后观察组患者血小板聚集率为(39.26±2.21)%,对照组血小板聚集率为(43.78±2.23)%,观察组患者血小板聚集率明显低于对照组,两组比较差异具有显著性(P＜0.05).观察组心绞痛复发12例(35.29%),再住院8例(23.52%),明显低于对照组的24例(70.59%)、17例(50.00%),两组比较差异具有显著性(P＜0.05),且对照组有1例中风患者.观察组出现恶心呕吐1例,对照组出现恶心呕吐2例,无其他明显副作用.结论氢氯吡格雷与辛伐他汀联合治疗急性冠脉综合征效果确切,值得应用.
목적 탐토경록필격뢰여신벌타정연합치료급성관맥종합정(ACS)적림상효과.방법 장2007년1월-2009년5월간재아원치료적ACS환자64례수궤분위관찰조화대조조,대조조급여상규치료조시,관찰조동시급여경록필격뢰여신벌타정연합치료조시.결과 량조환자혈소판취집솔비교:치료후관찰조환자혈소판취집솔위(39.26±2.21)%,대조조혈소판취집솔위(43.78±2.23)%,관찰조환자혈소판취집솔명현저우대조조,량조비교차이구유현저성(P＜0.05).관찰조심교통복발12례(35.29%),재주원8례(23.52%),명현저우대조조적24례(70.59%)、17례(50.00%),량조비교차이구유현저성(P＜0.05),차대조조유1례중풍환자.관찰조출현악심구토1례,대조조출현악심구토2례,무기타명현부작용.결론 경록필격뢰여신벌타정연합치료급성관맥종합정효과학절,치득응용.
Objective To explore the efficacy of clopidogrel combined with simvastatin for acute coronary syndrome (ACS). Methods 64 patients with ACS in our hospital from January 2007 to May 2009 were randomly assigned to receive conventional therapies (control group) or combination therapy with clopidogrel and simvastatin (study group). Results The decrease in hs-CRP level was markedly greater in the study group than in the control group (P＜0.05). The reduction in blood lipids did not differ significantly between the two groups (P＞0.05). The rates of platelet aggregation,recurrence of angina pectoris,and rehospitalization were significantly lower in the study group than in the control group (P＜0.05 for all comparisons). No obvious adverse reactions were found in the two groups. Conclusions Combination therapy with clopidogrel and simvastatin is effective in the treatment of acute coronary syndrome.