CAJ | 학술논문

本文对临床诊断为"急性乙型肝炎"和抗-HBc-IgM阳性的61,例患者用ELISA间接法检测特异性抗-HBc-IgG,发现其中28例(45.9%)急性期抗-HBc-IgG阴性,8～17个月后随访其中24例,HBsAg均阴转,19例(79.2%)抗-HBs阳转,5例(20.8%)抗-HBe阳转,SGPT均恢复正常.随访结果表明他们为初次感染HBV的急性乙型肝炎.另外33例(54.1%)急性期抗-HBc-IgG阳性病例,随访其中24例,HBsAg均持续阳性,其中8例(33.3%)临床复发,无1例产生抗-HBs,提示他们为持续感染HBV的慢性乙型肝炎.最后结果表明,抗-HBc-IgM和抗-HBc-IgG可作为临床鉴别HBV初次急性感染和既往持续感染的免疫学指标.
본문대림상진단위"급성을형간염"화항-HBc-IgM양성적61,례환자용ELISA간접법검측특이성항-HBc-IgG,발현기중28례(45.9%)급성기항-HBc-IgG음성,8～17개월후수방기중24례,HBsAg균음전,19례(79.2%)항-HBs양전,5례(20.8%)항-HBe양전,SGPT균회복정상.수방결과표명타문위초차감염HBV적급성을형간염.령외33례(54.1%)급성기항-HBc-IgG양성병례,수방기중24례,HBsAg균지속양성,기중8례(33.3%)림상복발,무1례산생항-HBs,제시타문위지속감염HBV적만성을형간염.최후결과표명,항-HBc-IgM화항-HBc-IgG가작위림상감별HBV초차급성감염화기왕지속감염적면역학지표.
Sixty-one patients with positive IgM anti-HBc,clinically diagnosed as"acute hepatitis B",were prospecMvely studied.Among them 28(45.9%)were IgG anti-HBc negative at the onset of illness identified as primary acute hepatitis B and 24 were followed up for 8 ～17 months.HBsAg disappeared and SGPT turned to normal in all the 24 cases;19(79.2%)developed anti-HBs,and the remaining 5(20.8%)had anti-HBe.On the other hand,33(54.1%)were IgG anti-HBc positive at the onset of illness identified as chronic hepatiiis B with previous HBV infeorion.Twenty-four of them were followed up.All the cases were persistently positive HBsAg,8(33.3%)of them had clinical recurrence of the disease.Thus,the deteclion of specific IgG and IgM anti-HBc is of great significance in the serological differentation of acute hepatitis B with primary infection from chronlo hepatitis B with previous infection.