中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
7期
74-76
,共3页
红细胞血型不规则抗体%微柱凝胶抗球蛋白试验%输血
紅細胞血型不規則抗體%微柱凝膠抗毬蛋白試驗%輸血
홍세포혈형불규칙항체%미주응효항구단백시험%수혈
Irregular antibodies of erythrocyte group ( IAEG )%Microcolumn gel antiglobin test%Blood transfusion
目的 调查肿瘤患者中红细胞血型不规则抗体的检出率及各种特异性不规则抗体的分布特点,并探讨其在安全输血中的临床意义.方法 手术备血患者23 000例,其中男19 769例,女13 231例,采用微柱凝胶抗球蛋白卡进行红细胞血型不规则抗体筛查,对初筛阳性者进行特异性抗体鉴定;对需要输血的患者准备相应抗原阴性的红细胞.结果 ①23 000例样本中检测出红细胞血型不规则抗体者118例,检出率0.51%,其中男性检出率为0.29%(58/19 769)、女性检出率为0.45%(60/13 231),其中以抗-Lea、抗-M、Rh系统的抗体、抗-P1及非特异性抗体较为多见;②118例抗体阳性者,有输血史或妊娠史者89例,其中检出的Rh抗体均有输血史及妊娠史;无输血史或妊娠史者29例,以抗-Lea、抗-M、抗-P1为多见,无Rh系统抗体;③为37例初筛阳性的患者准备了相合红细胞,其中4例进行了相合输血.结论 红细胞血型不规则抗体检出率女性高于男性(χ2=30.10,P＜0.0001),其中有临床意义的抗体多分布于有妊娠史或输血史的患者,这对保证输血安全具有重要的临床意义.
目的 調查腫瘤患者中紅細胞血型不規則抗體的檢齣率及各種特異性不規則抗體的分佈特點,併探討其在安全輸血中的臨床意義.方法 手術備血患者23 000例,其中男19 769例,女13 231例,採用微柱凝膠抗毬蛋白卡進行紅細胞血型不規則抗體篩查,對初篩暘性者進行特異性抗體鑒定;對需要輸血的患者準備相應抗原陰性的紅細胞.結果 ①23 000例樣本中檢測齣紅細胞血型不規則抗體者118例,檢齣率0.51%,其中男性檢齣率為0.29%(58/19 769)、女性檢齣率為0.45%(60/13 231),其中以抗-Lea、抗-M、Rh繫統的抗體、抗-P1及非特異性抗體較為多見;②118例抗體暘性者,有輸血史或妊娠史者89例,其中檢齣的Rh抗體均有輸血史及妊娠史;無輸血史或妊娠史者29例,以抗-Lea、抗-M、抗-P1為多見,無Rh繫統抗體;③為37例初篩暘性的患者準備瞭相閤紅細胞,其中4例進行瞭相閤輸血.結論 紅細胞血型不規則抗體檢齣率女性高于男性(χ2=30.10,P＜0.0001),其中有臨床意義的抗體多分佈于有妊娠史或輸血史的患者,這對保證輸血安全具有重要的臨床意義.
목적 조사종류환자중홍세포혈형불규칙항체적검출솔급각충특이성불규칙항체적분포특점,병탐토기재안전수혈중적림상의의.방법 수술비혈환자23 000례,기중남19 769례,녀13 231례,채용미주응효항구단백잡진행홍세포혈형불규칙항체사사,대초사양성자진행특이성항체감정;대수요수혈적환자준비상응항원음성적홍세포.결과 ①23 000례양본중검측출홍세포혈형불규칙항체자118례,검출솔0.51%,기중남성검출솔위0.29%(58/19 769)、녀성검출솔위0.45%(60/13 231),기중이항-Lea、항-M、Rh계통적항체、항-P1급비특이성항체교위다견;②118례항체양성자,유수혈사혹임신사자89례,기중검출적Rh항체균유수혈사급임신사;무수혈사혹임신사자29례,이항-Lea、항-M、항-P1위다견,무Rh계통항체;③위37례초사양성적환자준비료상합홍세포,기중4례진행료상합수혈.결론 홍세포혈형불규칙항체검출솔녀성고우남성(χ2=30.10,P＜0.0001),기중유림상의의적항체다분포우유임신사혹수혈사적환자,저대보증수혈안전구유중요적림상의의.
Objective To investigate the positive rate of irregular antibodies of erythrocyte group (IAEG) in tumor patients and distribution characteristic of several kinds of specific antibodies, while exploring the clinical significance of IAEG in safe blood transfusion.Methods 23000 cases of patients who would be possible to accept blood transfusion during future surgical operation were detected for irregular antibodies by microcolumn gel antiglobin test and specific antibodies were analysed among the positive cases, while preparing suitable erythrocyte products without the antigen corresponding to the detected antibodies.Results ①There are 118 positive cases among 23000 samples(0.51%) and the positive rates of male and female are 0.29% (58/19769) and 0.45% (60/13231) separately.Anti-Lea, Anti-M, Anti-Rh, Anti-P1 and unspecific antibodies are the main antibodies among them.②There are 89 cases of patients with the history of blood transfusion or gestation and 29 cases of patients with none of them among 118 positive cases.③Suited blood transfusion were prepared for 37 cases and were conducted for 4 cases of patients.Conclusion The positive rate of IAEG in female group are significantly higher than that in male group (χ2 = 30.10, P ＜ 0.0001 ) and significative antibodies mainly distribute in patients who had history of blood transfusion or gestation.The detecting of IAEG are important to safeguard the blood infusion.
