CAJ | 학술논문

背景严重心力衰竭时,可能存在内源性脑钠肽相对不足和/或脑钠肽的抵抗.B型脑钠肽(B-type natriuretic peptide,BNP)因在心力衰竭的诊断、治疗及预后判断的特殊价值而备受关注.奈西立肽是重组人脑钠肽,已成为治疗心力衰竭的一种新药.目的了解BNP与围术期心力衰竭的关系及其重组体--奈西立肽临床应用.内容 BNP与围术期心力衰竭的关系及其重组体--奈西立肽临床应用的研究现状.趋向围术期BNP水平与心衰的严重程度呈正相关,可用于心力衰竭的诊断、治疗及预后的判断.奈西立肽对围术期心力衰竭的患者具有很好的疗效,必将逐步应用于临床.
배경 엄중심력쇠갈시,가능존재내원성뇌납태상대불족화/혹뇌납태적저항.B형뇌납태(B-type natriuretic peptide,BNP)인재심력쇠갈적진단、치료급예후판단적특수개치이비수관주.내서립태시중조인뇌납태,이성위치료심력쇠갈적일충신약.목적 료해BNP여위술기심력쇠갈적관계급기중조체--내서립태림상응용.내용 BNP여위술기심력쇠갈적관계급기중조체--내서립태림상응용적연구현상.추향 위술기BNP수평여심쇠적엄중정도정정상관,가용우심력쇠갈적진단、치료급예후적판단.내서립태대위술기심력쇠갈적환자구유흔호적료효,필장축보응용우림상.
Background The relative deficiency and/or resistance of B-type natriuretic peptide (BNP) may in severe heart failure, BNP has attracted more attention because of its special clinical value in diagnosis,prognosis and treatment of heart failure.Nesiritide is a recombinant human BNP (rhBNP) and is a new drug to treat heart failure. Purpose This paper is to elucidate the relationship between BNP and perioperative heart failure, and the clinical using of nesiritide. Content We will review the relationship between BNP and perioperative heart failure, and the clinical application of the recombinant human BNP-nesiritide. Trend BNP has special clinical value in diagnosis, prognosis and treatment of heart failure because of its close correlation with the soverity of heart failure. The definite therapeutic effect of nesiritide maks it a promising agent for the treatment of perioperative heart failure.