CAJ | 학술논문

合成并表征了两个新的配合物:[Cu(HCP)(TBZ)](NO3)2·(H2O):(1)和[Cu(HCP)(HPB)](NO3)2·(H2O)15 (2)[HCP=环丙沙星,TBZ=2-(4'-噻唑基)苯并咪唑,HPB=2-(2-呲啶)-苯并咪唑].配合物1属于三斜晶系,P1空间群,a=0.9095(2)nm,b:1.3301(3)nm,c=1.3552(3)nm,α=93.518(3)°,β=97.192(3)°γ=106.361(3)°,V=1.5526(6)nm3,Z=2,Dc=1.598 g·cm-3,μ=0.849 mm-1.用二倍稀释法研究了配合物的抗菌活性,发现配合物对大肠杆菌(Escherichia coli,G-)、沙门氏杆菌(Salmonella,G-)和枯草杆菌(Bacillus subtilis,G+)具有良好的抑制作用.应用电子吸收光谱、荧光光谱、粘度测定及凝胶电泳研究了配合物与DNA的作用,结果表明配合物以插入方式与DNA作用,在维生素C存在下通过·OH切割pBR322 DNA双螺旋结构.
합성병표정료량개신적배합물:[Cu(HCP)(TBZ)](NO3)2·(H2O):(1)화[Cu(HCP)(HPB)](NO3)2·(H2O)15 (2)[HCP=배병사성,TBZ=2-(4'-새서기)분병미서,HPB=2-(2-자정)-분병미서].배합물1속우삼사정계,P1공간군,a=0.9095(2)nm,b:1.3301(3)nm,c=1.3552(3)nm,α=93.518(3)°,β=97.192(3)°γ=106.361(3)°,V=1.5526(6)nm3,Z=2,Dc=1.598 g·cm-3,μ=0.849 mm-1.용이배희석법연구료배합물적항균활성,발현배합물대대장간균(Escherichia coli,G-)、사문씨간균(Salmonella,G-)화고초간균(Bacillus subtilis,G+)구유량호적억제작용.응용전자흡수광보、형광광보、점도측정급응효전영연구료배합물여DNA적작용,결과표명배합물이삽입방식여DNA작용,재유생소C존재하통과·OH절할pBR322 DNA쌍라선결구.
Two new complexes:[Cu(HCP)(TBZ)I(NO3)2·(H2O)2(1)and[Cu(HCP)(HPB)](NO3)2·(H2O)1.5(2),where HCP=ciprofloxacin,TBZ=2-(4'-thiazolyl) benzimidazole,and HPB=2-(2-pyridyl) benzimidazole,were synthesized and characterized.Complex 1 crystallizes in the triclinic space group P1 in a unit cell of a=0.909 5 (2)nm,b=1.330 1(3)nm,c=1.355 2(3)nm,α=93.518(3)°,β=97.192(3)°,γ=106.361(3)°,V=1.552 6(6)nm3,Z=2,Dc=1.598dilutions method,and the interaction of the complexes to DNA Was investigated by electronic absorption spectroscopy,fluorescence spectroscopy,viscosity measurement and agarose gel electrophoresis.The results show that the complexes have good antibacterial activities,could interact with DNA by an intercalative mode,and cleave pBR322DNA in the presence of vitamin C in the involvement of the hydroxyl radical in the cleavage process.CCDC:762717.