CAJ | 학술논문

目的研究继发性骨髓纤维化(SMF)患者的临床特点和骨髓活检结果 .方法 80例SMF患者采用网状纤维染色(Gomori),并根据阳性结果判定纤维化程度.结果 80例患者其主要病因为造血系统恶性疾病(87.5%),以慢性骨髓增殖性疾病最多(占32.5%).就诊时网状纤维阳性程度以"++"～"+++"为主.患者就诊时血红蛋白、血小板与原发性骨髓纤维化存在明显差异(P<0.05).结论对初诊的造血系统恶性疾病患者应行骨髓活检检查,并在判断治疗过程中密切监测骨髓活检,以判断患者在疾病发展过程中是否合并骨髓纤维化,判定患者病情预后情况.
목적 연구계발성골수섬유화(SMF)환자적림상특점화골수활검결과 .방법 80례SMF환자채용망상섬유염색(Gomori),병근거양성결과 판정섬유화정도.결과 80례환자기주요병인위조혈계통악성질병(87.5%),이만성골수증식성질병최다(점32.5%).취진시망상섬유양성정도이"++"～"+++"위주.환자취진시혈홍단백、혈소판여원발성골수섬유화존재명현차이(P<0.05).결론 대초진적조혈계통악성질병환자응행골수활검검사,병재판단치료과정중밀절감측골수활검,이판단환자재질병발전과정중시부합병골수섬유화,판정환자병정예후정황.
Objective To study the clinical features and results of bone marrow biopsy of secondary myelofibrosis(SMF).Methods The Gomori method was used to judge if the patients had MF or were not SMF patients.Results The most important etiology of 80 SMF cases were malignant disease of hematological system(87.5%),among them CMPD were most important(32.5%).The level of reticulin fiber were from"++"～"+++".The level of HGB and PLT in SMF patients had obviously compared with those in IFM patients(P<0.05).Conclusion bone marrow biopsy may be used to intinal malignant disease of hematological system patients,and survey the condition of patients,judge if the patients had MF or not early,and the outcome of patients.