CAJ | 학술논문

目的研究音乐对大鼠空间学习和记忆的影响及对大鼠海马内NMDA受体的表达的影响.方法用Morris水迷宫中,位置非匹配任务行为检测方法,检测音乐刺激后,大鼠学习和记忆行为能力的变化,并用免疫组织化学、PCR技术,检测大鼠海马NMDA受体及编码NMDA受体的mRNA表达的变化.结果音乐刺激后,大鼠空间记忆能力改善,信息游泳逃和选择游泳逃避潜伏期缩短,选择游泳选择正确率提高;海马神经元NMDA受体及其mRNA表达增加.这些变化以持续音乐刺激组变化最明显,生后音乐组次之,对照组变化最小.结论音乐刺激能提高大鼠空间记忆能力,能增强大鼠海马神经元NMDA受体表达,增强海马组织编码NMDA受体的mRNA表达.
목적 연구음악대대서공간학습화기억적영향급대대서해마내NMDA수체적표체적영향.방법 용Morris수미궁중,위치비필배임무행위검측방법,검측음악자격후,대서학습화기억행위능력적변화,병용면역조직화학、PCR기술,검측대서해마NMDA수체급편마NMDA수체적mRNA표체적변화.결과 음악자격후,대서공간기억능력개선,신식유영도화선택유영도피잠복기축단,선택유영선택정학솔제고;해마신경원NMDA수체급기mRNA표체증가.저사변화이지속음악자격조변화최명현,생후음악조차지,대조조변화최소.결론 음악자격능제고대서공간기억능력,능증강대서해마신경원NMDA수체표체,증강해마조직편마NMDA수체적mRNA표체.
Objective: To study the effect of music on spatial learning and memory and the expression of the NMDA receptor in rat hippocampus. Methods:The no-matched position task in the Morris's water maze was used to examine the behavior changes on learning and memory , and immunohistochemistry and PCR technique were carried out to measure the expression of NMDA receptor and mRNA coding the receptor on hippocampus from Wistar rats after music stimulation. Results:After music exposure the spatial memory of rats improved; the avoiding latency of information swim and choice swim shortened, and choice accuration in choice swim increased; the expression of NMDA receptor and the mRNA coding the NMDA receptor on hippocampus was strengthened. All these effects were the strongest in the persistent music treated group, moderate in the postnatal music treated group, and least in the control groups. Conclusion:Music can improve the spatial memory of rats and increase the expression of the NMDA receptor and the mRNA coding the NMDA receptor in hippocampus.