CAJ | 학술논문

的：研究青藤碱对慢性肾炎的药理作用。方法：采用 C-BSA 复制家兔膜性肾小球肾炎模型，用青藤碱进行实验性治疗。结果：青藤碱能使模型动物尿蛋白、血 Cr 与 BUN、循环免疫复合物(CIC)、及血与尿中的 β2 微球蛋白(β2-MG)均明显降低。用青藤碱治疗的动物，肾小球平均直径和肾小球内细胞数均低于模型组。结论：青藤碱在减轻肾小球免疫性炎症、改善肾功能方面有较好的作用。
적：연구청등감대만성신염적약리작용。방법：채용 C-BSA 복제가토막성신소구 신염모형，용청등감진행실험성치료。결과：청등감능사모형동물뇨단백、혈 Cr 여 BUN、 순배면역복합물(CIC)、급혈여뇨중적 β2 미구단백(β2-MG)균명현강저。용청등감치 료적동물，신소구평균직경화신소구내세포수균저우모형조。결론：청등감재감경신소구면 역성염증、개선신공능방면유교호적작용。
Objective:To study the pharmacological action of si nomenine on chron ic nephritis. Methods: The membranous glomerulonephritis rabbit model was induce d by cationized bovine serum albumin (C-BSA) and then treated with sinomenine. R esults: Sinomenine could significantly reduce urine protein, serum creatinine an d blood urea nitrogen, circulatory immunocomplex and β2-nicroglobulin in blood and urine of model animals. The mean diameter and the number of cell in glomerul us in sinomenine treatment group were lower than in control model group. Conclus ion: Sinomenine exerts a good effect in alleviating glomerular immune inflammat ion and in improving renal function.