CAJ | 학술논문

探讨膀胱移行细胞癌中血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）的表达及与血管形成定量的关系。应用免疫组织化学方法，对62例原发性膀胱移行细胞癌组织中VEGF、bFGF进行检测，并对其在30例浸润性膀胱癌组织中的表达与血管形成的定量关系进行相关性研究。结果发现，膀胱癌组织中VEGF、bFGF阳性表达率分别为56.5％和46.8％，与病理分级、临床分期、复发和预后有关（P＜0.05）；并与浸润性癌组织中微血管定量呈正相关（P＜0.01，P＜0.05）。提示VEGF、bFGF是膀胱癌血管形成的主要血管生成因子，血管形成与膀胱癌发生和发展密切相关。
탐토방광이행세포암중혈관내피생장인자（VEGF）화감성성섬유세포생장인자（bFGF）적표체급여혈관형성정량적관계。응용면역조직화학방법，대62례원발성방광이행세포암조직중VEGF、bFGF진행검측，병대기재30례침윤성방광암조직중적표체여혈관형성적정량관계진행상관성연구。결과발현，방광암조직중VEGF、bFGF양성표체솔분별위56.5％화46.8％，여병리분급、림상분기、복발화예후유관（P＜0.05）；병여침윤성암조직중미혈관정량정정상관（P＜0.01，P＜0.05）。제시VEGF、bFGF시방광암혈관형성적주요혈관생성인자，혈관형성여방광암발생화발전밀절상관。
To investigate the expression of vascular endothelial growth factor(VEGF) and basic fibroblast growth factor(bFGF) in primary transitional cell carcinoma(TCC) of bladder,and to determine their relationship with magnitude of angiogenesis.Both growth factor were assayed using immunohistochemical technique in 62 cases of TCC.The relationship between the expression of VEGF and bFGF in invasive neoplastic tissues and magnitude of angiogenesis were also investigated.The positive expression rates of VEGF and bFGF in neoplastin tissues were 56.5% and 46.8%,respectively.The expression of VEGF and bFGF showed positive relationship with tumor grades,stages,high recurrence, and shorter survival(P＜0.05).The expression of VEGF and bFGF in invasive TCC was correlated with the magnitude of angiogenesis(P＜0.01，P＜0.05).VEGF and bFGF are two major angiogenic growth factors, and angiogenesis might play an important role in the development and invasiveness of TCC.