CAJ | 학술논문

【目的】探讨中药通腑醒神胶囊(由番泻叶、虎杖、人工牛黄粉等组成)治疗高血压性中、大量脑出血的作用机理。【方法】观察该方对双肾双夹法和注射胶原酶Ⅶ及肝素造成肾血管性高血压性脑出血模型大鼠的脑组织病理学、超微结构、脑血管通透性和脑组织含水量等指标的影响。【结果】通腑醒神胶囊灌胃组大鼠在脑组织病理学、超微结构的损伤方面较模型对照组轻，在改善脑血管通透性和降低脑组织含水量等方面与模型对照组比较差异均有显著性(P＜0.05)。【结论】该方可以改善脑出血后大鼠脑毛细血管通透性及减轻脑水肿，促进血肿吸收，减轻脑组织受压，改善微循环和脑组织供血供氧而达到保护脑组织、改善神经功能的目的，这是该方治疗高血压性中、大量脑出血临床有效的可能作用机理之一。
【목적】탐토중약통부성신효낭(유번사협、호장、인공우황분등조성)치료고혈압성중、대량뇌출혈적작용궤리。【방법】관찰해방대쌍신쌍협법화주사효원매Ⅶ급간소조성신혈관성고혈압성뇌출혈모형대서적뇌조직병이학、초미결구、뇌혈관통투성화뇌조직함수량등지표적영향。【결과】통부성신효낭관위조대서재뇌조직병이학、초미결구적손상방면교모형대조조경，재개선뇌혈관통투성화강저뇌조직함수량등방면여모형대조조비교차이균유현저성(P＜0.05)。【결론】해방가이개선뇌출혈후대서뇌모세혈관통투성급감경뇌수종，촉진혈종흡수，감경뇌조직수압，개선미순배화뇌조직공혈공양이체도보호뇌조직、개선신경공능적목적，저시해방치료고혈압성중、대량뇌출혈림상유효적가능작용궤리지일。
【Objective】 To explore the mechanism of Tongfu Xingshen Granule(TXG) for hypertensive middle- and large-amount cerebral hemorrhage.【Methods】Rat mod e ls with renal vascular hypertensive cerebral hemorrhage were established by occl usion of bilateral renal arteries and injection of collagenase and heparin,and t hen were allocated to TXG treatment group(Group A),mannitol treatment group(grou p B)and model control group (Group C).Indices such as brain pathomorphological f eatures,ultrastructure,vascular permeabilit y and water volume were observed.【Results】The above indices were improved in G roup A as compared Group C(P＜0.05). 【Conclusion】 TXG can protect brain tissue and improve nervous fu n ction.Its possible mechanism is by reducing the permeability of cerebral capilla ries and brain water volume,enhancing the absorption of hematoma,lowering the c erebral pressure,improving microcirculation and the supply of blood and oxygen.