CAJ | 학술논문

以合成的聚己内酯(PCL)、聚丙交酯(PLLA)及它们的共聚物(PCLLA)为材料,通过沉淀法制备了PCL、PLLA、PCLLA纳米微粒。透射电子显微镜和激光粒度仪分析表明,获得的纳米微粒具有较小的尺寸和粒径分布。同时还研究了水相温度、聚合物的分子量以及聚合物材料本身性质对纳米微粒粒径大小和分布的影响。
이합성적취기내지(PCL)、취병교지(PLLA)급타문적공취물(PCLLA)위재료,통과침정법제비료PCL、PLLA、PCLLA납미미립。투사전자현미경화격광립도의분석표명,획득적납미미립구유교소적척촌화립경분포。동시환연구료수상온도、취합물적분자량이급취합물재료본신성질대납미미립립경대소화분포적영향。
Biodegradable homopolymers and copolymers of ε-caprolactone and L-lactide were synthesized by ring-opening polymerization at 120 ℃ using stannous octoate as a catalyst. Nanoparticles of these polymers were prepared by precipitation method. The morphological examination of nanoparticles was performed by means of a transmission electron microscope, and the mean particle size and size distribution were measured by laser light scattering technique. The effects of polymer composition, temperature of the aqueous phase and molecular weight of the polymer on particle size were investigated. The results indicate that the particle size of the copolymers is smaller than that of the homopolymers. With the increase of water phase temperature, the particle size decreases and the yield of nanoparticle increases. On the contrary, with the increase of the polymer molecular weight, the particle size increases and the yiled of nanoparticle decreases.