CAJ | 학술논문

目的探讨高压氧治疗噪声性听力损伤的作用机理和疗效。方法将声损伤豚鼠分别进行高压氧(Ⅰ)、复方丹参(Ⅱ)、高压氧+复方丹参(Ⅲ)治疗。疗程结束后测定脑干听区诱发电位听阈的变化及耳蜗的葡萄糖、丙酮酸含量。结果葡萄糖含量噪声损伤组低于对照组，高压氧组(Ⅰ)高于噪声损伤组；丙酮酸含量噪声损伤组与其它组均有差异；丙酮酸/葡萄糖比值高压氧组(Ⅰ)、高压氧+丹参组(Ⅲ)均低于噪声损伤组，噪声损伤组高于对照组。高压氧组(Ⅰ)听力损失12.5dB(A)，高压氧+丹参组(Ⅲ)听力损伤仅为2.5dB(A)。结论高压氧治疗噪声性听力损伤有肯定的疗效，高压氧+丹参治疗噪声性听力损伤有协同作用，而丹参单独治疗尚不能认为有效。
목적탐토고압양치료조성성은력손상적작용궤리화료효。방법장성손상돈서분별진행고압양(Ⅰ)、복방단삼(Ⅱ)、고압양+복방단삼(Ⅲ)치료。료정결속후측정뇌간은구유발전위은역적변화급이와적포도당、병동산함량。결과포도당함량조성손상조저우대조조，고압양조(Ⅰ)고우조성손상조；병동산함량조성손상조여기타조균유차이；병동산/포도당비치고압양조(Ⅰ)、고압양+단삼조(Ⅲ)균저우조성손상조，조성손상조고우대조조。고압양조(Ⅰ)은력손실12.5dB(A)，고압양+단삼조(Ⅲ)은력손상부위2.5dB(A)。결론고압양치료조성성은력손상유긍정적료효，고압양+단삼치료조성성은력손상유협동작용，이단삼단독치료상불능인위유효。
Objective To study the mechanisms of action and the curative effect of the hyperbaric oxygen treating the noiseinduced hearing impairment. Methods Hearing impaired guinea pigs were treated separately with hyperbaric oxygen (Ⅰ), radix salviae miltiorrhiza co (Ⅱ) , hyperbaric oxygen and radix salviae miltiorrhiza co(Ⅲ). Measure the audition threshold change of the brain stem audition area evoked potential; and the content of the glucose and pyruvic acid in the cochlea were measured after the end of treatment. Results The content of the glucose: the impaired group is lower than the control group, the ( Ⅰ ) group is higher than the impaired group. The content of the pyruvic acid: the impaired group is different with all the other groups. The ratio of pyruvic acid/glucose:(Ⅰ)group and (Ⅲ) group both are lower than the impaired group, the impaired group is higher than the control group. The hearing impairment of (Ⅰ) group is 12.5dB(A), while that of (Ⅲ) group is only 2.5dB(A). Conclusion Treating the noise-induced hearing impairment with hyperbaric oxygen has a definite curative effect, the hyperbaric oxygen and radix salviae miltiorrhiza co together has a synergism, and the radix salviae miltiorrhiza co alone can't be effective surely.