CAJ | 학술논문

采用4种不同肿瘤模型的荷瘤小鼠,观察了CMNa对受照小鼠肿瘤的作用.结果表明:与单纯照射组相比,CMNa能明显地减慢肿瘤的生长速度; 增加肿瘤生长的延迟天数,4种肿瘤模型均得到相同的结果.绝大多数SER值在1.3 以上.实验结果表明,CMNa对体内肿瘤亦有明显的放射增敏作用.然而在相似条件下,以CFU-GM为指标,在研究CMNa对受照正常小鼠对射线敏感的造血组织有否影响时,却未观察到CMNa对正常组织的放射增敏效应,与单纯照射组相比,CFU-GM无变化,SER=1,其治疗增益指数(TGF)均在1.3以上.提示:CMNa将有希望成为临床肿瘤治疗有效的新型放疗增敏药.
채용4충불동종류모형적하류소서,관찰료CMNa대수조소서종류적작용.결과표명:여단순조사조상비,CMNa능명현지감만종류적생장속도; 증가종류생장적연지천수,4충종류모형균득도상동적결과.절대다수SER치재1.3 이상.실험결과표명,CMNa대체내종류역유명현적방사증민작용.연이재상사조건하,이CFU-GM위지표,재연구CMNa대수조정상소서대사선민감적조혈조직유부영향시,각미관찰도CMNa대정상조직적방사증민효응,여단순조사조상비,CFU-GM무변화,SER=1,기치료증익지수(TGF)균재1.3이상.제시:CMNa장유희망성위림상종류치료유효적신형방료증민약.
The aim of this study was to see whether Sodium Glycididazole (CMNa) could enhance the in situ tumor efficacy ofradiation,using 4 different tumor models bearing mice.The results showed that incomparison with the irradiated group alone,CMNa could decrease the velocity of tumorgrowth and increase the days of Tumor Growth Delay(TGD) evidently in all four tumortypes.CMNa showed radiosensitizing activity for all tumors with SERs greater than1.3.It demonstrates that the novel radiosensitizer can potentiate the in situanti-tumor efficacy of radiation and has different radiosensitization effect amongthe tested tumors.Whether the new radiosensitizer CMNa has any effects on normaltissue such as radiosensitive bone marrow was tested.Survival of bonemarrow stemcells(CFU-GM) due to radiation alone or in combination with the drug was assessed.Nevertheless it did not enhance the radiosensitizing effect on normal bonemarrow and SER=1.The Therapeutic Gain Factor(TGF) defined as SER of tumor divided by SER of normaltissue bone marrow is greater than 1.3.Maybe CMNa will be an effective new typeradiosensitive drug for clinical cancer therapy.