CAJ | 학술논문

为考核并比较甲型肝炎减毒活疫苗（甲肝疫苗）的免疫学效果，对314名易感儿童随机分为3组，分别接种市售昆明、杭州、长春3个厂家生产的甲肝疫苗，免疫后21、34天采血检测抗－HAV。结果显示：免疫后21天3个厂家甲肝疫苗抗－HAV阳转率分别为61.9％、60.9％和80.0％，免疫后34天分别为71.6％、66.7％和44.9％，国产高滴度甲肝疫苗安全性好，但疫苗质量有待进一步提高，以获得更好的免疫学效果。
위고핵병비교갑형간염감독활역묘（갑간역묘）적면역학효과，대314명역감인동수궤분위3조，분별접충시수곤명、항주、장춘3개엄가생산적갑간역묘，면역후21、34천채혈검측항－HAV。결과현시：면역후21천3개엄가갑간역묘항－HAV양전솔분별위61.9％、60.9％화80.0％，면역후34천분별위71.6％、66.7％화44.9％，국산고적도갑간역묘안전성호，단역묘질량유대진일보제고，이획득경호적면역학효과。
To evaluate and compare the immune effects of three kinds of domestic live attenuated hepatits A vaccines, 314 anti-hepatitis A virus(HAV)antibody negative children were randomly divided into 3 groups and vaccinated with commercial live attenuated hepatitis A vaccines made in Kunming, Hangzhou and Changchun respectively. Serum samples collected 21 and 34 days after inoculation were tested for anti-HAV. The vaccines produced in 3 factories all had a similar positive seroconversion rates of 61.9%, 60.9% and 80.0% 21 days after, vaccination and a significantly differential rates of 71.6%, 66.7% and 44.9% 34 days after. The results suggested that China-made live attenuated hepatits A vaccine with higher titer is safe, but the quality need to be improved to get a better immune efficacy.