CAJ | 학술논문

Objective. To investigate the effects of Ginkgo biloba extract (Egb) on cerebral vasospasm (CVS) after subarachnoid hemorrhage(SAH)and its influence on nitric oxide (NO) and endothelin-l(ET-1). Methods. Noncraniotomy models of SAH in Wistar rats were used and animals were divided into sham-operated group, SAH group, saline-treated group and Egb-treated group. Diameter of basilar artery was measured. Regional cerebral blood flow(rCBF),NO and ET-1 levels in blood,and calcium content in brain tissue within 24 hours after SAH were detected. Pathological examination of hippocampus CA1 sub field was also performed. Results. Sham operation did not alter the above parameters. Induction of SAH led to a marked spasm of basilar artery. rCBF decreased obviously and consecutively within 24 hours after SAH. Meanwhile NO level in serum decreased, ET-1 level in plasma and calcium content in brain tissue significantly in creased. Pyramidal cells in hippocampus CA1 subfield were severely damaged. Egb significantly antago nized the pathological alterations of the above parameters. Conclusion. Alterations of NO, and ET-1 play an important role in the development of CVS after SAH. Egb exerts its protective effects on CVS by inhibitng the above pathological alterations.