CAJ | 학술논문

失重状态对机体多系统产生影响.研究显示,模拟失重可导致肺组织微血管发生重建,肺组织的超微结构变化,以及肺组织细胞凋亡及其调控基因异常表达等改变.失重早期还可导致肺损伤,继而启动一系列创伤免疫炎症反应致大量炎性细胞因子释放,不仅影响非特异性免疫应答,对特异性免疫应答也有显著影响.失重对呼吸系统影响的深入研究将对航天事业的医疗保障有重要意义.
실중상태대궤체다계통산생영향.연구현시,모의실중가도치폐조직미혈관발생중건,폐조직적초미결구변화,이급폐조직세포조망급기조공기인이상표체등개변.실중조기환가도치폐손상,계이계동일계렬창상면역염증반응치대량염성세포인자석방,불부영향비특이성면역응답,대특이성면역응답야유현저영향.실중대호흡계통영향적심입연구장대항천사업적의료보장유중요의의.
Experiments performed during real and simulated microgravity have shown substantial changes in multisystem on body.Simulated microgravity may result in microvascular reconstruction,ultrastructural changes of the lung tissue,changes of cell apoptosis and abnormal expression of the regulatory gene,etc.Weightless can also lead to pulmonary tissue damage,initiate a series of traumatic immune and inflammatory responses,and inflammatory cytokine release.These changes not only affect non-specific immune response,but also affect the specific immune response significantly.Further research about weightless would play a significant role in the health care during spaceflight.