CAJ | 학술논문

目的观察和评价三联疗法(自血疗法联合咪唑斯汀、雷尼替丁)治疗慢性荨麻疹的临床疗效、安全性及对血清总lgE水平影响.方法将110例慢性荨麻疹随机分为治疗组55例,对照组55例,对照组口服咪唑斯汀缓释片,10mg,每天1次.治疗组采用三联疗法,在对照组用药的基础上口服雷尼替丁胶囊0.15g,每天2次,再联合自血疗法,从患者的静脉里抽取5 ml血液.随即直接注射到病人臀部的深层肌肉,3天1次,两组疗程均为30天.两组患者同时检测治疗前及停药后血清总IgE含量,并和病情变化进行相关性分析.观察两组患者疗程结束后、停药3个月后疗效,评价其安全性,比较治疗前及停药后血清总IgE变化,结果疗程结束后(近期)治疗组有效率为90.1%,对照组有效率为87.3%,近期疗效差异无显著性(P＞0.05).停药3个月(远期)治疗组有效率为83.6%,对照组有效率为56.4%,远期疗效差异有极显著性(P＜0.01).两组患者随访三个月,治疗组复发4例(15.4%),对照组复发11例(47.8%)两组复发率差异有显著性(P＜0.05).两组血液总lgE水平治疗前差异无显著性(P＞0.05),停药后治疗组总lgE水平降低较明显,与治疗前及对照组比较均差异有极显著性(P＜0.01).结论采用三联疗法瀹疗慢性荨麻疹疗效显著,远期疗效理想,能减少复发,明显降低患者血清中总IgE水平,副作用少,值得临床应用.
목적 관찰화평개삼련요법(자혈요법연합미서사정、뢰니체정)치료만성담마진적림상료효、안전성급대혈청총lgE수평영향.방법 장110례만성담마진수궤분위치료조55례,대조조55례,대조조구복미서사정완석편,10mg,매천1차.치료조채용삼련요법,재대조조용약적기출상구복뢰니체정효낭0.15g,매천2차,재연합자혈요법,종환자적정맥리추취5 ml혈액.수즉직접주사도병인둔부적심층기육,3천1차,량조료정균위30천.량조환자동시검측치료전급정약후혈청총IgE함량,병화병정변화진행상관성분석.관찰량조환자료정결속후、정약3개월후료효,평개기안전성,비교치료전급정약후혈청총IgE변화,결과료정결속후(근기)치료조유효솔위90.1%,대조조유효솔위87.3%,근기료효차이무현저성(P＞0.05).정약3개월(원기)치료조유효솔위83.6%,대조조유효솔위56.4%,원기료효차이유겁현저성(P＜0.01).량조환자수방삼개월,치료조복발4례(15.4%),대조조복발11례(47.8%)량조복발솔차이유현저성(P＜0.05).량조혈액총lgE수평치료전차이무현저성(P＞0.05),정약후치료조총lgE수평강저교명현,여치료전급대조조비교균차이유겁현저성(P＜0.01).결론 채용삼련요법약료만성담마진료효현저,원기료효이상,능감소복발,명현강저환자혈청중총IgE수평,부작용소,치득림상응용.
Objective To observe and evaluate the clinical effect and safety with triple therapy, namely the auto-blood therapy combined with mizolastine and ranitidine hydrochloride capsules, in treating the chronic urticaria patients, and the effect on the level changes of Immunoglobulin E (IgE). Methods The 110 chronic urticaria patients were randomly divided into control group, which included 55 patients taking orally mizolastine 10 mg one time a day for 30 days, and the treatment group, including 55 patients treated with triple therapy, which took orally mizolastine 10 mg one time a day plus ranitidine hydrochloride capsules 0.15 mg each time, twice a day, combined with auto-blood therapy which injected 5 ml blood from each patient's vein into their huttock muscles every 3 days, for 30 days. We tested the level of IgE of control group and the treatment group before and after the treatment, and analyzed it with the change of condition of the patients. Then we observed the effect with triple therapy in both of the groups at the end of the course and 3 months after the course respectively, evaluated its safety, and compare the levels of IgE before and after the treatment. Results After the course, the effective rate is 90.1% in treatment group and 87.3% in control group. There was no statistic difference in recent effect (P＞ 0.05). 3 months after the course, the effective rate is 83.6% in treatment group and 56.4% in control group. There is statistic difference in long-term effect (P＜0.01). A follow-up survey of 3 months showed that 4 cases (15.4%) in treatment group and11 cases (47.8%) of control group (58.3%) were relapsed. There was statistic difference in relapse rate between two groups (P＞0.05). Before the treatment, there was no statistic difference in the level of IgE between two groups(P＞0.05).But after the treatment,there was significant decrease in the level of IgE in the treatment group,which was statistically different from the level before the treatment and that in the control group.Conclusion It is very effective for the chronic urticaria patients treated with triple therapy,showing on the long-term effect especially.Triple therapy can reduce the relapse rate,significantly deerease the level of lgE of the patients and has less side effects thus worthy for clinical application.