CAJ | 학술논문

肿瘤血管生成与肿瘤的生长、恶变、转移以及患者的预后有着密切的关系,因此,肿瘤的抗血管生成治疗引起了人们的极大兴趣.分子影像学应用高亲和力的分子探针与靶分子特异性结合的原理,可在活体细胞和分子水平上特征性地显示及测量生物机体的生化过程.近年来,分子影像学技术在肿瘤血管生成的可视化及定量研究中取得了一定的进展,有望成为肿瘤早期诊断与靶向治疗评价的重要手段.该文综述了肿瘤血管生成的分子影像学技术的最新进展.
종류혈관생성여종류적생장、악변、전이이급환자적예후유착밀절적관계,인차,종류적항혈관생성치료인기료인문적겁대흥취.분자영상학응용고친화력적분자탐침여파분자특이성결합적원리,가재활체세포화분자수평상특정성지현시급측량생물궤체적생화과정.근년래,분자영상학기술재종류혈관생성적가시화급정량연구중취득료일정적진전,유망성위종류조기진단여파향치료평개적중요수단.해문종술료종류혈관생성적분자영상학기술적최신진전.
Tumor angiogenesis has a close relationship with tumor growth,progression,metastasis and the prognosis of tumor patients.Therefore,tumor anti-angiogenic treatment arouses great public interest.Molecular imaging can characteristically display and measure the biochemical process of organisms at cellular and molecular level in vivo,which is based on the specific binding of molecular probe with high affinity and target molecules.In recent years,molecular imaging has a certain progress on visual and quantitative research of tumor angiogenesis and it is expected to become an important technique in the efficacy evaluation and prognostic assessment.This article summarizes the new advances of molecular imaging technology in tumor angiogenesis.