CAJ | 학술논문

目的探讨真菌及棘阿米巴混合感染性角膜炎的发病、临床特征、诊断及其治疗.方法对2007年7月至2008年12月在福建医科大学附属第一医院确诊的19例真菌及棘阿米巴混合感染性角膜炎进行回顾性临床分析,分析其发病诱因、诊断方法及临床特征,采用抗真菌及阿米巴药物或结膜瓣遮盖术或穿透性角膜移植术进行治疗并观察疗效.结果 19例确诊病例中,14例发病与角膜外伤有关,3例与角膜接触镜相关;所有病例通过角膜刮片镜检,或真菌与阿米巴培养确诊;16例表现为角膜局部溃疡型,3例表现为基质环形浸润;5例经药物治愈,11例经结膜瓣遮盖治愈,2例行穿透性角膜移植术(PKP).结论真菌及棘阿米巴混合感染性角膜炎的发病诱因以角膜外伤为主,角膜刮片镜检是早期诊断的有效方法,综合药物和手术治疗对感染的控制具有重要意义.
목적 탐토진균급극아미파혼합감염성각막염적발병、림상특정、진단급기치료.방법 대2007년7월지2008년12월재복건의과대학부속제일의원학진적19례진균급극아미파혼합감염성각막염진행회고성림상분석,분석기발병유인、진단방법급림상특정,채용항진균급아미파약물혹결막판차개술혹천투성각막이식술진행치료병관찰료효.결과 19례학진병례중,14례발병여각막외상유관,3례여각막접촉경상관;소유병례통과각막괄편경검,혹진균여아미파배양학진;16례표현위각막국부궤양형,3례표현위기질배형침윤;5례경약물치유,11례경결막판차개치유,2례행천투성각막이식술(PKP).결론 진균급극아미파혼합감염성각막염적발병유인이각막외상위주,각막괄편경검시조기진단적유효방법,종합약물화수술치료대감염적공제구유중요의의.
Objective To study the etiology, clinical features, diagnosis and treatment of patients with combined fungal and acanthamoeba kerafitis.Methods Nineteen cases of combined fungal and acanthamoeba keratitis at the First Affiliated Hospital of Fujian Medical University between July 2007 and May 2008 were retrospectively reviewed.Predisposing factors, diagnosis, and clinical characteristics of the patients were analyzed. The patients were received medications or conjunctival flap covering or penetrating keratoplasty (PKP).Results Patients in this series, risk factors included corneal trauma (14/19) and contact lens wear (3/19).Patients were confirmed by corneal scraping and microscopic examination, and/or fungal/amoeba culture.Sixteen cases were showed corneal local ulcer, and 3 cases were ring-shaped stromal infiltration. Five cases were cured by combined anti-amoeba and anti-fungal drug therapy, and 11 patients were healed by conjunctival flap covering, and 2 patients performed PKP.Conclusions The main risk factor of combined fungal and acanthamoeba keratitis is corneal trauma.Scraping and microscopic examination is an effective method for early diagnosis.Anti-amoeba/fungal drug therapy combined with conjunctival flap covering is an effective method to treat this keratitis.