CAJ | 학술논문

目的探讨脉络膜新生血管性疾病患者在接受中西药治疗后的视功能改变,客观评价多焦视网膜电图(mfERG)及视野在脉络膜新生血管膜形成(choroidal neovasculari-zation,CNV)病程临测中的应用价值.方法收集中山大学中山眼科中心2007年至2009年经FFA及ICGA确诊湿性型AMD、特发性CNV患者接受中西药联合治疗共14例(16只眼),于治疗前、治疗后3个月、6个月分别行视力、眼底彩照、视野、多焦视网膜电图检查,分析治疗过程中的形态学和功能改变.结果治疗后6个月中心30°视野平均缺损(MD)、丢失变异(LV)明显下降(P<0.05),中心10°视野LV明显下降(P<0.05);治疗后6个月mfERG第3环、第5环N1波振幅密度比治疗前明显增加,其差异有统计学意义(P(3R)=0.03,P(5R)=0.021);治疗后6个月mfERG第1环、第2环P1波振幅密度比治疗前明显增加,其差异有统计学意义(P(1R)=0.012,P(2R)=0.036).结论中西药结合治疗对CNV患者的视功能有稳定或改善的作用.
목적 탐토맥락막신생혈관성질병환자재접수중서약치료후적시공능개변,객관평개다초시망막전도(mfERG)급시야재맥락막신생혈관막형성(choroidal neovasculari-zation,CNV)병정림측중적응용개치.방법 수집중산대학중산안과중심2007년지2009년경FFA급ICGA학진습성형AMD、특발성CNV환자접수중서약연합치료공14례(16지안),우치료전、치료후3개월、6개월분별행시력、안저채조、시야、다초시망막전도검사,분석치료과정중적형태학화공능개변.결과 치료후6개월중심30°시야평균결손(MD)、주실변이(LV)명현하강(P<0.05),중심10°시야LV명현하강(P<0.05);치료후6개월mfERG제3배、제5배N1파진폭밀도비치료전명현증가,기차이유통계학의의(P(3R)=0.03,P(5R)=0.021);치료후6개월mfERG제1배、제2배P1파진폭밀도비치료전명현증가,기차이유통계학의의(P(1R)=0.012,P(2R)=0.036).결론 중서약결합치료대CNV환자적시공능유은정혹개선적작용.
Objective To evaluate visual function in patients with CNV treated with Chinesemedicine combined with antioxygen, and objectively assess the value of multifocal electroretinogram and visual field in the follow-up of patient with CNV.Methods Fourteen patients (16 eyes) with CNV treated with traditional Chinese medicine combined with antioxygen were enrolled from 2007 to 2009.Their BCVA, FFA and/or ICGA, visual field and mfERG were performed at baseline and at 3 months, 6 months to evaluate the effects of the treatment.Results The mean defect (MD) and the loss variance (LV) of central 30° visual field and the LV of central 10° visual field was significantly decreased at sixth month (P <0.05); The average response density of N1 and P1 in the first and second ring were increased than baseline (P, 1st ring = 0.012; P, 2nd ring = 0.031) in the follow up of 6 months.Conclusions The visual function of patients with CNV may be stable or improved with the combined treatment of traditional Chinese medicine and antioxigen.