早产儿血清瘦素及多种生长相关激素水平研究
조산인혈청수소급다충생장상관격소수평연구
Serum levels of leptin and several growth-related hormones in premature infants
  • 万方数据
    中华儿科杂志 중화인과잡지
    Chinese Journal of Pediatrics
    2009年 2期 134-139 ,共6页

    房晓祎%翁立坚%林霓阳%周秀吟%黄巧凤

    방효의%옹립견%림예양%주수음%황교봉

    瘦素%早产儿%体重%神经肽Y%胰岛素%胰岛素样生长因子-1 瘦素%早產兒%體重%神經肽Y%胰島素%胰島素樣生長因子-1
    수소%조산인%체중%신경태Y%이도소%이도소양생장인자-1
    Leptin%Premature infant%Weight%Neuropeptide Y%Insulin%Insulin-like growth factor-1
    目的 瘦素(leptin,LEP)主要由脂肪组织产生,参与机体能量代谢、调节生长发育.本研究通过检测早产儿不同日龄(第1、7、12天)的体重指数(body mass index,BMI)、头围(headcircumference,HC)及血清LEP、神经肽Y(neuropeptide Y,NPY)、胰岛素(insulin,INS)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)水平,探讨早产儿血清LEP及多种生长相关激素水平变化与体重变化的关系.方法 70例早产儿中患严重疾病的早产儿40例(患病组)、未患严重疾病的早产儿30例(对照组),测最出生第1、7、12天时体重、身长、头围,计算BMI,应用放射免疫分析法检测相应日龄血清LEP、NPY、INS、IGF-1水平.结果 (1)患病组早产儿生后第1、7、12天血清LEP分别为0.74±21、0.60±0.18、0.82±0.12(mg/L)(P<0.01),BMI分别为9.81±1.24、8.36±0.87、9.08±1.12(kg/m2)(P<0.01);对照组早产儿生后第1、7、12天血清LEP分别为0.78±0.17、0.71±0.17、0.88±0.58(mg/L)(P<0.01),BMI分别为10.03±1.04、9.35±0.80、11.06±0.82(kg/m2)(P<0.01).两组早产儿血清LEP水平,第1天差异无统计学意义(P>0.05),第7、12天患病组均低于对照组(P<0.01).(2)患病组及对照组早产儿不同日龄血清LEP与BMI均存在正相关关系.(3)患病组早产儿生后第1、7、12天血清NPY水平,分别为55.33±9.38、46.64±6.17、75.13±9.12(ng/L)(P<0.01),血清INS水平分别为10.07±2.63、7.71±2.77、10.37±2.29(mU/L)(P<0.01),血清IGF-1水平分别为38.66±11.42、31.98±7.34、41.84±8.05(mg/L)(P<0.01).对照组早产儿在生后第1、7、12天血清NPY水平,分别为57.77±7.15、48.49±8.81、81.36±8.51(ng/L)(P<0.01),血清INS分别为11.55±1.99、8.28±2.87、15.42±3.80(mU/L)(P<0.01),血清IGF-1水平,分别为37.76±7.07、34.33±8.97、50.19±8.38(mg/L)(P<0.01).患病组及对照组早产儿生后第1、7、12天血清LEP水平及BMI与相应日龄血清NPY、INS、IGF-1水平,分别存在正相关关系.结论 (1)随着早产儿出生早期BMI、HC先下降冉回升的变化趋势,血清LEP水平也有相应的变化,提示LEP与早产儿出生早期的体重变化有关系.(2)患严重疾病早产儿血清LEP水平明显下降.(3)LEP可能与NPY、INS、IGF-1之间相互关联,共同影响早产儿体重变化.
    목적 수소(leptin,LEP)주요유지방조직산생,삼여궤체능량대사、조절생장발육.본연구통과검측조산인불동일령(제1、7、12천)적체중지수(body mass index,BMI)、두위(headcircumference,HC)급혈청LEP、신경태Y(neuropeptide Y,NPY)、이도소(insulin,INS)、이도소양생장인자-1(insulin-like growth factor-1,IGF-1)수평,탐토조산인혈청LEP급다충생장상관격소수평변화여체중변화적관계.방법 70례조산인중환엄중질병적조산인40례(환병조)、미환엄중질병적조산인30례(대조조),측최출생제1、7、12천시체중、신장、두위,계산BMI,응용방사면역분석법검측상응일령혈청LEP、NPY、INS、IGF-1수평.결과 (1)환병조조산인생후제1、7、12천혈청LEP분별위0.74±21、0.60±0.18、0.82±0.12(mg/L)(P<0.01),BMI분별위9.81±1.24、8.36±0.87、9.08±1.12(kg/m2)(P<0.01);대조조조산인생후제1、7、12천혈청LEP분별위0.78±0.17、0.71±0.17、0.88±0.58(mg/L)(P<0.01),BMI분별위10.03±1.04、9.35±0.80、11.06±0.82(kg/m2)(P<0.01).량조조산인혈청LEP수평,제1천차이무통계학의의(P>0.05),제7、12천환병조균저우대조조(P<0.01).(2)환병조급대조조조산인불동일령혈청LEP여BMI균존재정상관관계.(3)환병조조산인생후제1、7、12천혈청NPY수평,분별위55.33±9.38、46.64±6.17、75.13±9.12(ng/L)(P<0.01),혈청INS수평분별위10.07±2.63、7.71±2.77、10.37±2.29(mU/L)(P<0.01),혈청IGF-1수평분별위38.66±11.42、31.98±7.34、41.84±8.05(mg/L)(P<0.01).대조조조산인재생후제1、7、12천혈청NPY수평,분별위57.77±7.15、48.49±8.81、81.36±8.51(ng/L)(P<0.01),혈청INS분별위11.55±1.99、8.28±2.87、15.42±3.80(mU/L)(P<0.01),혈청IGF-1수평,분별위37.76±7.07、34.33±8.97、50.19±8.38(mg/L)(P<0.01).환병조급대조조조산인생후제1、7、12천혈청LEP수평급BMI여상응일령혈청NPY、INS、IGF-1수평,분별존재정상관관계.결론 (1)수착조산인출생조기BMI、HC선하강염회승적변화추세,혈청LEP수평야유상응적변화,제시LEP여조산인출생조기적체중변화유관계.(2)환엄중질병조산인혈청LEP수평명현하강.(3)LEP가능여NPY、INS、IGF-1지간상호관련,공동영향조산인체중변화.
    Objective Leptin (LEP) is mainly produced by white adipose tissue and participates in the energy metabolism and regulation of growth. Cooperating with the other metabolic hormones, it plays an important role in the developments of fetus and neonates. This study was designed to test the serum levels of LEP, neuropeptide Y (NPY), insulin (INS) and insulin-like growth factor-1 (IGF-1) and measure the body mass index (BMI) and head circumference (HC) at different days of life of premature infants with or without serious diseases and to find the ehanges of serum levels of LEP as well as NPY, INS and IGF-1, the relationship between those hormones and the changes of body weight and the influences of diseases on the levels of those hormones in premature infants. Method The clinical data as well as weights, lengths, HC of 40 sick premature infants (sick group) and 30 premature infants without any diseases (control group) were collected and the serum levels of LEP, NPY, INS and IGF-1 were determined by using radioimmunoassay (RIA) at d 1, d 7 and d 12 of life. BMI was calculated by weight (kg)/length (m)2. SPSS13.0 was used to analyze the data . Result (1) In sick group the serum LEP levels were 0.74±0.21,0.60±0.18, 0.82±0.12 (mg/L) (P<0.01), the BMI were 9. 81±1.24, 8.36±0.87, 9.08±1.12 (kg/m2) (P<0.01) on d 1, d 7 and d 12, respectively. In control group serum LEP levels were 0.78±0.17, 0.71±0.17, 0.88±0.58 (mg/L) (P<0.01), the BMI were 10.03±1.04, 9.35±0.80, 11.06±0.82 (kg/m2), on d 1, d 7 and d 12, respectively (P<0.01). In both groups, serum LEP levels as well as the BMI decreased on d 7 and reincreased on d 12. The differences of serum LEP levels and BMI between sick group and control group at d1 were not significant (P>0.05); compared with control group, the serum LEP levels and BMI on d 7 and d 12 in sick group were lower and the differences were significant. (2)There were positive correlations between serum LEP levels and BMI in sick group as well as in control group. (3) In sick group, the serum NPY levels at d 1, d 7, d 12 were 55.33±9.38, 46.64±6.17, 75.13±9. 12 (ng/L) (P<0.01), INS were 10.07±2.63, 7.71±2.77, 10.37±2.29 (mU/L) (P<0.01), IGF-1 were 38.66±11.42, 31.98±7.34, 41.84±8.05 (mg/L) (P<0.01), respectively. In control group, the serum NPY levels at dl, d 7 and d 12 were 57.77±7.15, 48.49±8. 81,81.36±8.51 (ng/L) (P<0.01), INS were 11.55±1.99, 8.28±2. 87, 15.42±3. 80 (mU/L) (P<0.01), IGF-1 were37.76±7.07, 34.33±8.97, 50.19±8.38 (mg/L) (P<0.01), respectively. In both groups, serum levels of NPY, INS and IGF-1 had positive correlations with serum LEP levels as well as BMI on the corresponding days and decreased on d 7 and reincreased on d 12. Conclusion (1) The serum LEP levels decreased on 7 d of life and reincreased on 12 d of life, which corresponded to the changes of the physical development of premature infants. (2) The serum LEP levels in sick premature infants decreased definitely as compared with control group, which suggested that diseases had negative influences on the LEP levels and the physical developments were slowed down in sick premature infants. (3) The serum levels of NPY, INS and IGF-1 had positive correlations with LEP levels as well as BMI at the early period of life, which suggested that NPY, INS and IGF-1, cooperating with LEP, might take part in the regulation of development of premature infants.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문