临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2009年
8期
1032-1034
,共3页
COPD%沙美特罗替卡松(舒利迭)%孟鲁斯特钠(顺尔宁)%肺功能
COPD%沙美特囉替卡鬆(舒利迭)%孟魯斯特鈉(順爾寧)%肺功能
COPD%사미특라체잡송(서리질)%맹로사특납(순이저)%폐공능
chronic obstructive pulmonary disease (COPD)%salmeterol/fluticasone propionate (seretide)%montelukast sodium (singulair)%lung function
目的 探讨沙美特罗替卡松(舒利迭)联合孟鲁斯特钠(顺尔宁)对慢性阻塞性肺疾病(COPD)患者肺功能的影响.方法 40例患者随机分为舒利迭组(对照组)和舒利迭加顺尔宁组(试验组)各20例.两组入院期间均给于常规抗感染﹑吸氧﹑化痰和平喘对症治疗.对照组加用舒利迭,试验组加用舒利迭和顺尔宁,两组平喘治疗包括普通氨茶碱,按需使用喘康速气雾剂(特布他林).出院后对照组继续使用舒利迭,试验组继续使用舒利迭和顺尔宁,共随访观察12周.两组均于治疗前查肺功能,治疗症状好转出院,12周后再次测定上述指标.结果 两组治疗前肺功能无明显差异;治疗后两组肺功能较治疗前均有显著改善.试验组较对照组第一秒用力呼气容积(FEV1)、用力肺活量(FVC)﹑第一秒用力呼气容积/用力肺活量(FEV1/FVC)和第一秒用力呼气容积占预计值百分比(FEV1%Pred)等明显改善,差异有显著性;试验组较对照组每天按需使用特布他林次数减少,差异有显著性.结论 舒利迭和顺尔宁共同作用对COPD患者肺功能更有显著的改善作用.
目的 探討沙美特囉替卡鬆(舒利迭)聯閤孟魯斯特鈉(順爾寧)對慢性阻塞性肺疾病(COPD)患者肺功能的影響.方法 40例患者隨機分為舒利迭組(對照組)和舒利迭加順爾寧組(試驗組)各20例.兩組入院期間均給于常規抗感染﹑吸氧﹑化痰和平喘對癥治療.對照組加用舒利迭,試驗組加用舒利迭和順爾寧,兩組平喘治療包括普通氨茶堿,按需使用喘康速氣霧劑(特佈他林).齣院後對照組繼續使用舒利迭,試驗組繼續使用舒利迭和順爾寧,共隨訪觀察12週.兩組均于治療前查肺功能,治療癥狀好轉齣院,12週後再次測定上述指標.結果 兩組治療前肺功能無明顯差異;治療後兩組肺功能較治療前均有顯著改善.試驗組較對照組第一秒用力呼氣容積(FEV1)、用力肺活量(FVC)﹑第一秒用力呼氣容積/用力肺活量(FEV1/FVC)和第一秒用力呼氣容積佔預計值百分比(FEV1%Pred)等明顯改善,差異有顯著性;試驗組較對照組每天按需使用特佈他林次數減少,差異有顯著性.結論 舒利迭和順爾寧共同作用對COPD患者肺功能更有顯著的改善作用.
목적 탐토사미특라체잡송(서리질)연합맹로사특납(순이저)대만성조새성폐질병(COPD)환자폐공능적영향.방법 40례환자수궤분위서리질조(대조조)화서리질가순이저조(시험조)각20례.량조입원기간균급우상규항감염﹑흡양﹑화담화평천대증치료.대조조가용서리질,시험조가용서리질화순이저,량조평천치료포괄보통안다감,안수사용천강속기무제(특포타림).출원후대조조계속사용서리질,시험조계속사용서리질화순이저,공수방관찰12주.량조균우치료전사폐공능,치료증상호전출원,12주후재차측정상술지표.결과 량조치료전폐공능무명현차이;치료후량조폐공능교치료전균유현저개선.시험조교대조조제일초용력호기용적(FEV1)、용력폐활량(FVC)﹑제일초용력호기용적/용력폐활량(FEV1/FVC)화제일초용력호기용적점예계치백분비(FEV1%Pred)등명현개선,차이유현저성;시험조교대조조매천안수사용특포타림차수감소,차이유현저성.결론 서리질화순이저공동작용대COPD환자폐공능경유현저적개선작용.
Objective To explore the effects of combining salmeterol/fluticasone propionate (seretide) and montelukast sodium (singulair) on patients with COPD by analyzing lung function. Methods 40 patients with COPD were randomly divided into two groups: experimental group (20 cases) and control group (20 cases). The basic treatments for the two groups were antibiotics, oxygens inhalation, dissipate phlegm and antiasthma etc. The control group was given seretide;the experimental group was given seretide and singulair. Antiasthma treatments included aminophylline and bricasol (terbutaline) pro re nata. After leaving hospital, the control group continued using seretide;the experimental group continued using seretide and singulair for 12 weeks. All patients checked lung function before the treatment;Lung function was checked after 12 weeks. Results Before the treatment, lung function in the both groups were not statistically different (P＞0.05). After the treatment, there was improvement of lung function than before the treatment (P＜0.05). FEV1, FVC, FEV1/FVC and FEV1% Pred were superior in the experimental group to the control group. The experimental group used bricasol (terbutaline) less than the control group. Conclusion Combining seretide and singulair can improve lung fuction significantly.
