应用化工
應用化工
응용화공
APPLIED CHEMICAL INDUSTRY
2010年
1期
147-149
,共3页
梁俊%肖新荣%贾小鹏%谭雯文%谭彬
樑俊%肖新榮%賈小鵬%譚雯文%譚彬
량준%초신영%가소붕%담문문%담빈
盐酸安非他酮%邻氟苯丙酮%溴代%2-芳基-2-吗啉醇盐酸盐%合成
鹽痠安非他酮%鄰氟苯丙酮%溴代%2-芳基-2-嗎啉醇鹽痠鹽%閤成
염산안비타동%린불분병동%추대%2-방기-2-마람순염산염%합성
bupropion HCl%2-fluoropripiophenone%bromination%2-aryl-2-morpholinol hydrochloride%synthesis
1-(2-氟苯)-2-溴-1-丙酮在非质子极性溶剂中经胺化、环合反应,最后酸化得到3,5-二甲基-2-(2-氟苯)-2-吗啉醇盐酸盐(产率82.7%).其结构均得到IR和~1H NMR确证.整个合成路线具有反应条件温和、反应时间短、收率高等优点.
1-(2-氟苯)-2-溴-1-丙酮在非質子極性溶劑中經胺化、環閤反應,最後痠化得到3,5-二甲基-2-(2-氟苯)-2-嗎啉醇鹽痠鹽(產率82.7%).其結構均得到IR和~1H NMR確證.整箇閤成路線具有反應條件溫和、反應時間短、收率高等優點.
1-(2-불분)-2-추-1-병동재비질자겁성용제중경알화、배합반응,최후산화득도3,5-이갑기-2-(2-불분)-2-마람순염산염(산솔82.7%).기결구균득도IR화~1H NMR학증.정개합성로선구유반응조건온화、반응시간단、수솔고등우점.
2-(2-Fluorophenyl)-3,5-dimethyl-2-morpholinol hydrochloride was synthesized from 2-bromo-1-(2-fluorophenyl)-1-propanone via aminnation and cyclization in nonproton polar solvent,at last acidification by divergent synthetic method,with yield of 82.7%.Its structures was confirmed on by IR and ~1H NMR.The synthetic route has the advantages of easy operation,mild reaction condition,short reaction time and high yield.
