时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2011年
5期
1159-1160
,共2页
盐酸小檗碱%高效液相色谱%萸连缓释片%体内停留时间
鹽痠小檗堿%高效液相色譜%萸連緩釋片%體內停留時間
염산소벽감%고효액상색보%유련완석편%체내정류시간
目的 考察萸连缓释片胃内的滞留时间.方法 通过高效液相色谱(HPLC)法测定胃内盐酸小檗碱的残留量,以确定萸连缓释片在体内的滞留时间.结果 盐酸小檗碱进样量在2.681 5～18.769 μg·ml<'-1>浓度范围内与峰面积呈良好的线性关系(r=0.999 8,n=7),12 h时间段内萸连缓释片在胃内的含量分别为0.106,0.086,0.076,0.066,0.030,0.027,0.026 mg·ml<'-1>.结论 萸连缓释片在家兔胃内停留时间约为12 h.
目的 攷察萸連緩釋片胃內的滯留時間.方法 通過高效液相色譜(HPLC)法測定胃內鹽痠小檗堿的殘留量,以確定萸連緩釋片在體內的滯留時間.結果 鹽痠小檗堿進樣量在2.681 5～18.769 μg·ml<'-1>濃度範圍內與峰麵積呈良好的線性關繫(r=0.999 8,n=7),12 h時間段內萸連緩釋片在胃內的含量分彆為0.106,0.086,0.076,0.066,0.030,0.027,0.026 mg·ml<'-1>.結論 萸連緩釋片在傢兔胃內停留時間約為12 h.
목적 고찰유련완석편위내적체류시간.방법 통과고효액상색보(HPLC)법측정위내염산소벽감적잔류량,이학정유련완석편재체내적체류시간.결과 염산소벽감진양량재2.681 5～18.769 μg·ml<'-1>농도범위내여봉면적정량호적선성관계(r=0.999 8,n=7),12 h시간단내유련완석편재위내적함량분별위0.106,0.086,0.076,0.066,0.030,0.027,0.026 mg·ml<'-1>.결론 유련완석편재가토위내정류시간약위12 h.
