CAJ | 학술논문

目的评估全反式维甲酸(ATRA)、三氧化二砷(As2O3)、化疗联合治疗初诊急性早幼粒细胞白血病(APL)的疗效和患者不良反应.方法对40例采用ATRA、As2O3、化疗三联疗法治疗的APL患者的临床资料进行回顾性分析,观察其疗效及不良反应.结果总体CR率92.5%(37/40),完全缓解所需中位时间27(22～61)d;白细胞≥10×109/L组CR率72.7%(8/11),白细胞<10×109/L组CR率100%(29/29),差异有统计学意义(x2=8.550,P=0.004);治疗过程中无严重不良反应,仅1例发生维甲酸综合征.结论 ATRA、As2O3、化疗联合应用可作为APL患者的首选治疗方案.
목적 평고전반식유갑산(ATRA)、삼양화이신(As2O3)、화료연합치료초진급성조유립세포백혈병(APL)적료효화환자불량반응.방법 대40례채용ATRA、As2O3、화료삼련요법치료적APL환자적림상자료진행회고성분석,관찰기료효급불량반응.결과 총체CR솔92.5%(37/40),완전완해소수중위시간27(22～61)d;백세포≥10×109/L조CR솔72.7%(8/11),백세포<10×109/L조CR솔100%(29/29),차이유통계학의의(x2=8.550,P=0.004);치료과정중무엄중불량반응,부1례발생유갑산종합정.결론 ATRA、As2O3、화료연합응용가작위APL환자적수선치료방안.
Objective To observe the efficacy and side effects of combined therapy with victoria A acid,arsenic trioxide and chemotherapeutics for newly diagnosed acute promyelocytic leukemia (APL). Methods 40 cases of patients were treated with combined therapy of ATRA, As2O3 and chemotherapy. The efficacy and side effects were analysed. Results 92.5 % (37/40) achieved complete remission(CR). The CR time was 27(22-61) d by average; leukocytes≥ 10×109/L group complete remission was 72.7 % (8/11), leukocytes < 10×l09/L group complete remission was 100 % (29/29). There was a significant different (x2 =8.550, P =0.004). No severe side effects was observed except one who developed retinoic acid syndrom. Conclusion The combined regimen of ATRA and As2O3 with chemotherapy for acute promyelocytic leukemia should be the first choice management.