国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2008年
9期
583-586
,共4页
急性胰腺炎%白介素-18%APACHEⅡ评分
急性胰腺炎%白介素-18%APACHEⅡ評分
급성이선염%백개소-18%APACHEⅡ평분
acute poacreatitis%interleukin-18%APACHEⅡ score
目的 探索急性胰腺炎患者血清中自介素-18(IL-18)水平变化情况,及其与患者入院时APACHE Ⅱ评分及患者预后之间的关系.方法 按照急性胰腺炎的临床诊断及分级标准分组选择AP患者34例,其中重症胰腺炎(SAP)患者12例,轻型急性胰腺炎(MAP)患者22例,正常对照组16例.用ELISA法检测血清IL-18浓度.结果 血清中IL-18浓度在MAP和SAP两组患者之间均存在统计学差异(P<0.01),SAP组明显高于MAP组,且IL-18水平动态变化与APACHEⅡ评分呈正相关.结论 血清IL-18参与了急性胰腺炎的炎症反应过程,可以作为预测急性胰腺炎严重程度的指标.
目的 探索急性胰腺炎患者血清中自介素-18(IL-18)水平變化情況,及其與患者入院時APACHE Ⅱ評分及患者預後之間的關繫.方法 按照急性胰腺炎的臨床診斷及分級標準分組選擇AP患者34例,其中重癥胰腺炎(SAP)患者12例,輕型急性胰腺炎(MAP)患者22例,正常對照組16例.用ELISA法檢測血清IL-18濃度.結果 血清中IL-18濃度在MAP和SAP兩組患者之間均存在統計學差異(P<0.01),SAP組明顯高于MAP組,且IL-18水平動態變化與APACHEⅡ評分呈正相關.結論 血清IL-18參與瞭急性胰腺炎的炎癥反應過程,可以作為預測急性胰腺炎嚴重程度的指標.
목적 탐색급성이선염환자혈청중자개소-18(IL-18)수평변화정황,급기여환자입원시APACHE Ⅱ평분급환자예후지간적관계.방법 안조급성이선염적림상진단급분급표준분조선택AP환자34례,기중중증이선염(SAP)환자12례,경형급성이선염(MAP)환자22례,정상대조조16례.용ELISA법검측혈청IL-18농도.결과 혈청중IL-18농도재MAP화SAP량조환자지간균존재통계학차이(P<0.01),SAP조명현고우MAP조,차IL-18수평동태변화여APACHEⅡ평분정정상관.결론 혈청IL-18삼여료급성이선염적염증반응과정,가이작위예측급성이선염엄중정도적지표.
Objective To study the dynamic change and prognostic significance of serum IL-18 in acute pancreatitis,and to explore the relationship between the APACHE Ⅱ score and prognosis of. Acute pancreati-tis. Methods According to the clinical diagnosis and criteria for acute pancreatitis, 34 patients with AP were divided into severe acute pancreatitis (SAP) group( n = 12 ) and mild acute pancreatitis (MAP) group (n = 22). Sixteen normal individuals were used as the control group ( n = 16.). The serum IL-18 was detected by ELISA. Results IL-18 in the SAP group was higher than that in the MAP group. In the MAP group, there was significant positive correlation between APACHE Ⅱ and IL-18 ( r = 0.98 ,P < 0.01 ). Conclusion IL-18 plays an important role in the development of acute pancreatitis, and it may be a valuable index to predict the severity of AP.
