中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2012年
9期
709-711
,共3页
钱亚玲%徐承敏%路艳艳%唐红芳%阮征%王晗%朱海豹%刘丹华%张幸
錢亞玲%徐承敏%路豔豔%唐紅芳%阮徵%王晗%硃海豹%劉丹華%張倖
전아령%서승민%로염염%당홍방%원정%왕함%주해표%류단화%장행
二甲基乙酰胺%阈限值%甲基乙酰胺%尿
二甲基乙酰胺%閾限值%甲基乙酰胺%尿
이갑기을선알%역한치%갑기을선알%뇨
N,N-dimethylacetamide%Threshold limit value%N-methylacetamide%Urinary
目的 研制我国职业接触二甲基乙酰胺(DMAC)工人尿中甲基乙酰胺(NMAC)的生物限值.方法 选择3家氨纶生产企业201名接触DMAC工人,应用个体采样器采集工作周末工作日的车间空气样品,用气相色谱法检测个体DMAC接触水平,同时收集当日工人班末尿样,应用气相色谱法测定尿中NMAC浓度以评价DMAC接触工人内暴露水平.通过内外剂量的回归方程、百分位数和相对内暴露(RIE)指数计算,推荐我国职业接触二甲基乙酰胺工人尿中NMAC生物接触限值.结果 201名DMAC接触工人中接触浓度符合我国DMAC接触限值133名,占66.2%,接触浓度范围在0.40~300.12mg/m3,几何平均浓度为19.4 mg/m3.工作周末班未尿中NMAC浓度范围为1.30~189.42 mg/g Cr,几何平均浓度为23.7 mg/g Cr.尿中NMAC浓度与个体DMAC外暴露浓度有相关性(F=188.872,R2=0.487,P<0.001),回归方程为log(NMAC mg/g Cr)=0.685+0.455 log(DMAC mg/m3).以我国DMAC职业接触限值PC-TWA为20 mg/m3推算,尿中NMAC浓度为18.92 mg/g Cr.当工作场所空气中DMAC<20 mg/m3时,90%的工人尿中NMAC水平为23.9 mg/g Cr.按RIE指数推算的尿中NMAC为19.0 mg/g Cr.结论 参考国外DMAC生物接触限值标准,建议我国DMAC生物接触限值为工作周末班未尿中NMAC 20 mg/g Cr.
目的 研製我國職業接觸二甲基乙酰胺(DMAC)工人尿中甲基乙酰胺(NMAC)的生物限值.方法 選擇3傢氨綸生產企業201名接觸DMAC工人,應用箇體採樣器採集工作週末工作日的車間空氣樣品,用氣相色譜法檢測箇體DMAC接觸水平,同時收集噹日工人班末尿樣,應用氣相色譜法測定尿中NMAC濃度以評價DMAC接觸工人內暴露水平.通過內外劑量的迴歸方程、百分位數和相對內暴露(RIE)指數計算,推薦我國職業接觸二甲基乙酰胺工人尿中NMAC生物接觸限值.結果 201名DMAC接觸工人中接觸濃度符閤我國DMAC接觸限值133名,佔66.2%,接觸濃度範圍在0.40~300.12mg/m3,幾何平均濃度為19.4 mg/m3.工作週末班未尿中NMAC濃度範圍為1.30~189.42 mg/g Cr,幾何平均濃度為23.7 mg/g Cr.尿中NMAC濃度與箇體DMAC外暴露濃度有相關性(F=188.872,R2=0.487,P<0.001),迴歸方程為log(NMAC mg/g Cr)=0.685+0.455 log(DMAC mg/m3).以我國DMAC職業接觸限值PC-TWA為20 mg/m3推算,尿中NMAC濃度為18.92 mg/g Cr.噹工作場所空氣中DMAC<20 mg/m3時,90%的工人尿中NMAC水平為23.9 mg/g Cr.按RIE指數推算的尿中NMAC為19.0 mg/g Cr.結論 參攷國外DMAC生物接觸限值標準,建議我國DMAC生物接觸限值為工作週末班未尿中NMAC 20 mg/g Cr.
목적 연제아국직업접촉이갑기을선알(DMAC)공인뇨중갑기을선알(NMAC)적생물한치.방법 선택3가안륜생산기업201명접촉DMAC공인,응용개체채양기채집공작주말공작일적차간공기양품,용기상색보법검측개체DMAC접촉수평,동시수집당일공인반말뇨양,응용기상색보법측정뇨중NMAC농도이평개DMAC접촉공인내폭로수평.통과내외제량적회귀방정、백분위수화상대내폭로(RIE)지수계산,추천아국직업접촉이갑기을선알공인뇨중NMAC생물접촉한치.결과 201명DMAC접촉공인중접촉농도부합아국DMAC접촉한치133명,점66.2%,접촉농도범위재0.40~300.12mg/m3,궤하평균농도위19.4 mg/m3.공작주말반미뇨중NMAC농도범위위1.30~189.42 mg/g Cr,궤하평균농도위23.7 mg/g Cr.뇨중NMAC농도여개체DMAC외폭로농도유상관성(F=188.872,R2=0.487,P<0.001),회귀방정위log(NMAC mg/g Cr)=0.685+0.455 log(DMAC mg/m3).이아국DMAC직업접촉한치PC-TWA위20 mg/m3추산,뇨중NMAC농도위18.92 mg/g Cr.당공작장소공기중DMAC<20 mg/m3시,90%적공인뇨중NMAC수평위23.9 mg/g Cr.안RIE지수추산적뇨중NMAC위19.0 mg/g Cr.결론 삼고국외DMAC생물접촉한치표준,건의아국DMAC생물접촉한치위공작주말반미뇨중NMAC 20 mg/g Cr.
Objective To establish Biological Limit Value (BLV) forN,N-dimethylacetamide (DMAC).Method 201 workers in 3 spandex factories exposed to DMAC were recruited.Air samples were collected using personal air samplers,and urine samples from each works were collected at the end of shift at end of workweek.The urinary metabolite NMAC and air samples of DMAC were determined by gas chromatography (GC).Percentile and relative internal exposure (RIE) were analyzed and proposed a BLV for DMAC.Results The number of workers who exposure to DMAC below OELs were 133 (66.2%) among 201 workers monitored.Geometric mean (range) concentration of DMAC in air was 19.4 (0.40~300.12) mg/m3,and that of NMAC in urine was 23.7 (1.30~189.42) mg/g Cr.A linear correlation was found between the personal air DMAC and creatinine-adjusted NMAC levels in urine collected at the end of shift at end of workweek (F=188.872,R2=0.487,P<0.001).The relationship can be described by the equation Log (NMAC mg/g Cr)=0.685+0.455 log (DMAC mg/m3).According to the equation the current China OELs value of 20 mg/m3 would lead to a mean NMAC concentration of 18.92 mg/g Cr.The 90th percentile biomonitoring result below 20 mg/m3 8-hour TWA is 23.9 mg MMAC mg/g Cr,and that of NMAC in urine calculated by relative internal exposure (RIE) was 19.0 mg/g Cr.Conclusion A BLV of 20 mg/g Cr NMAC in urine at the end of shift at end of workweek for DMAC was recommend by reference to official values from other countries.