国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2011年
11期
853-856
,共4页
p38有丝分裂原激活蛋白激酶%信号传导%脑缺血%炎症%凋亡%预处理
p38有絲分裂原激活蛋白激酶%信號傳導%腦缺血%炎癥%凋亡%預處理
p38유사분렬원격활단백격매%신호전도%뇌결혈%염증%조망%예처리
p38 mitogen-activated protein kinases%Signal transduction%Brain ischemia%inflammation%apoptosis%preconditioning
p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是一类重要的细胞内信号转导通路,其主要作用是参与炎症调节和细胞凋亡.脑缺血时,p38 MAPK被激活,其表达水平以及上游和下游蛋白磷酸化水平均发生改变.缺血预处理可能通过p38 MAPK信号转导通路介导脑缺血后神经细胞的存亡.
p38絲裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是一類重要的細胞內信號轉導通路,其主要作用是參與炎癥調節和細胞凋亡.腦缺血時,p38 MAPK被激活,其錶達水平以及上遊和下遊蛋白燐痠化水平均髮生改變.缺血預處理可能通過p38 MAPK信號轉導通路介導腦缺血後神經細胞的存亡.
p38사렬원활화단백격매(mitogen-activated protein kinase,MAPK)시일류중요적세포내신호전도통로,기주요작용시삼여염증조절화세포조망.뇌결혈시,p38 MAPK피격활,기표체수평이급상유화하유단백린산화수평균발생개변.결혈예처리가능통과p38 MAPK신호전도통로개도뇌결혈후신경세포적존망.
p38 mitogen-activated protein kinase (MAPK) is an important intracellular signaling transduction pathway.Its major role is involved in inflammatory regulation and apoptosis.p38 MAPK is activated during the cerebral ischemia.Its expression level and the upstream and downstream protein phosphorylation levels will change.Ischemic preconditioning may mediate the survival or death of neuronal cells after cerebral ischemia through signaling transduction pathway.
