CAJ | 학술논문

目的探讨丝氨酸蛋白酶Omi/HtrA2在胃癌组织中的表达及其与胃癌临床病理特征及预后的关系.方法采用免疫组化法检测68例胃癌组织、15例癌旁组织及15例正常胃黏膜组织中Omi/HtrA2的表达,并分析其表达与胃癌临床病理特征及预后的关系.结果 Omi/HtrA2在胃癌组织中的阳性表达率为73.5%(50/68),高于癌旁组织(13.3%,2/15)和正常胃黏膜(6.7%,1/15),差异有统计学意义(P＜0.05).胃癌组织中Omi/HtrA2的表达与患者的性别、年龄、肿瘤大小及浸润深度无关(P＞0.05);与肿瘤的分化程度、淋巴结转移和临床分期有关(P＜0.05).本组胃癌患者5年总体生存率为63.3%,其中Omi/HtrA2表达阳性组和阴性组分别为72.0%和61.1%,两组比较,差异并无统计学意义(P＞0.05).结论 Omi/HtrA2在胃癌组织中高表达,其表达与胃癌分化程度、淋巴结转移及TNM分期有关,但并不影响胃癌患者的预后.
목적 탐토사안산단백매Omi/HtrA2재위암조직중적표체급기여위암림상병리특정급예후적관계.방법 채용면역조화법검측68례위암조직、15례암방조직급15례정상위점막조직중Omi/HtrA2적표체,병분석기표체여위암림상병리특정급예후적관계.결과 Omi/HtrA2재위암조직중적양성표체솔위73.5%(50/68),고우암방조직(13.3%,2/15)화정상위점막(6.7%,1/15),차이유통계학의의(P＜0.05).위암조직중Omi/HtrA2적표체여환자적성별、년령、종류대소급침윤심도무관(P＞0.05);여종류적분화정도、림파결전이화림상분기유관(P＜0.05).본조위암환자5년총체생존솔위63.3%,기중Omi/HtrA2표체양성조화음성조분별위72.0%화61.1%,량조비교,차이병무통계학의의(P＞0.05).결론 Omi/HtrA2재위암조직중고표체,기표체여위암분화정도、림파결전이급TNM분기유관,단병불영향위암환자적예후.
Objective To explore the expression of serine protease Omi/HtrA2 in gastric carcinoma tissue and its association with clinicopathological features and prognosis. Methods Omi/HtrA2 protein expression levels were detected by immunohistochemistry method in resected gastric carcinomas(n=68), adjacent noncancerous tissues(n=15), and normal tissues(n=15), and its association with clinicopathological features and prognosis were analyzed. Results Omi/HtrA2 expression was positive in 73.5%(50/68) of gastric cancer tissues, which was significantly higher than that in adjacent noncancerous tissues and normal tissues(P＜0.05). There were no significant differences in Omi/HtrA2 expression with respect to sex, age, tumor size, and depth of invasion(all P＞0.05). Omi/HtrA2 expression level was significantly associated with tumor differentiation, extent of lymph node metastasis, and tumor stage(all P＜0.05). Overall 5-year survival rate of patients with gastric carcinoma was 63.3%. Five-year survival rate was higher in Omi/HtrA2 positive cases than Omi/HtrA2 negative cases(72.0% vs. 61.1%), however the difference was not statistically significant. Conclusions Omi/HtrA2 expression is more common in gastric carcinoma. Omi/HtrA2 expression is associated with tumor differentiation, extent of lymph node metastasis, and tumor stage.